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Open AccessArticle

Anserine Reverses Exercise-Induced Oxidative Stress and Preserves Cellular Homeostasis in Healthy Men

1
Laboratory of Exercise Biochemistry, University of Taipei, No.101, Sec. 2, Zhongcheng Road., Shilin District, Taipei City 11153, Taiwan
2
School of Health and Life Sciences, Teesside University, Tees Valley, Middlesbrough TS1 3BA, UK
3
Office of Physical Education, Soochow University, No. 70, Linhsi Road, Shihlin District, Taipei City 11111, Taiwan
*
Authors to whom correspondence should be addressed.
Nutrients 2020, 12(4), 1146; https://doi.org/10.3390/nu12041146
Received: 24 February 2020 / Revised: 16 April 2020 / Accepted: 16 April 2020 / Published: 19 April 2020
(This article belongs to the Special Issue Muscle Strength and Muscle Quality in Relation to Nutrition)
The study tested whether anserine (beta-alanyl-3-methyl-l-histidine), the active ingredient of chicken essence affects exercise-induced oxidative stress, cell integrity, and haematology biomarkers. In a randomized placebo-controlled repeated-measures design, ten healthy men ingested anserine in either a low dose (ANS-LD) 15 mg·kg−1·bw−1, high dose (ANS-HD) 30 mg·kg−1·bw−1, or placebo (PLA), following an exercise challenge (time to exhaustion), on three separate occasions. Anserine supplementation increased superoxide dismutase (SOD) by 50% (p < 0.001, effect size d = 0.8 for both ANS-LD and ANS-HD), and preserved catalase (CAT) activity suggesting an improved antioxidant activity. However, both ANS-LD and ANS-HD elevated glutathione disulfide (GSSG), (both p < 0.001, main treatment effect), and consequently lowered the glutathione to glutathione disulfide (GSH/GSSG) ratio compared with PLA (p < 0.01, main treatment effect), without significant effects on thiobarbituric acid active reactive substances (TBARS). Exercise-induced cell damage biomarkers of glutamic-oxaloacetic transaminase (GOT) and myoglobin were unaffected by anserine. There were slight but significant elevations in glutamate pyruvate transaminase (GPT) and creatine kinase isoenzyme (CKMB), especially in ANS-HD (p < 0.05) compared with ANS-LD or PLA. Haematological biomarkers were largely unaffected by anserine, its dose, and without interaction with post exercise time-course. However, compared with ANS-LD and PLA, ANS-HD increased the mean cell volume (MCV), and decreased the mean corpuscular haemoglobin concentration (MCHC) (p < 0.001). Anserine preserves cellular homoeostasis through enhanced antioxidant activity and protects cell integrity in healthy men, which is important for chronic disease prevention. However, anserine temporal elevated exercise-induced cell-damage, together with enhanced antioxidant activity and haematological responses suggest an augmented exercise-induced adaptative response and recovery. View Full-Text
Keywords: anserine; nutraceutical; exercise recovery; oxidative stress; cell damage; haematocrit anserine; nutraceutical; exercise recovery; oxidative stress; cell damage; haematocrit
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MDPI and ACS Style

Alkhatib, A.; Feng, W.-H.; Huang, Y.-J.; Kuo, C.-H.; Hou, C.-W. Anserine Reverses Exercise-Induced Oxidative Stress and Preserves Cellular Homeostasis in Healthy Men. Nutrients 2020, 12, 1146. https://doi.org/10.3390/nu12041146

AMA Style

Alkhatib A, Feng W-H, Huang Y-J, Kuo C-H, Hou C-W. Anserine Reverses Exercise-Induced Oxidative Stress and Preserves Cellular Homeostasis in Healthy Men. Nutrients. 2020; 12(4):1146. https://doi.org/10.3390/nu12041146

Chicago/Turabian Style

Alkhatib, Ahmad; Feng, Wen-Hsin; Huang, Yi-Jen; Kuo, Chia-Hua; Hou, Chien-Wen. 2020. "Anserine Reverses Exercise-Induced Oxidative Stress and Preserves Cellular Homeostasis in Healthy Men" Nutrients 12, no. 4: 1146. https://doi.org/10.3390/nu12041146

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