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Open AccessArticle

Muscle Phenotype, Proteolysis, and Atrophy Signaling During Reloading in Mice: Effects of Curcumin on the Gastrocnemius

1
Pulmonology Department-Muscle Wasting and Cachexia in Chronic Respiratory Diseases and Lung Cancer Research Group, IMIM-Hospital del Mar, Parc de Salut Mar, Barcelona Biomedical Research Park (PRBB), 08003 Barcelona, Spain
2
Health and Experimental Sciences Department (CEXS), Universitat Pompeu Fabra (UPF), Barcelona Biomedical Research Park (PRBB), 08003 Barcelona, Spain
3
Centro de Investigación en Red de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III (ISCIII), 08003 Barcelona, Spain
*
Author to whom correspondence should be addressed.
Nutrients 2020, 12(2), 388; https://doi.org/10.3390/nu12020388
Received: 18 November 2019 / Revised: 24 December 2019 / Accepted: 24 January 2020 / Published: 31 January 2020
(This article belongs to the Special Issue Muscle Strength and Muscle Quality in Relation to Nutrition)
We hypothesized that curcumin may mitigate muscle protein degradation and loss through attenuation of proteolytic activity in limb muscles of mice exposed to reloading (7dR) following immobilization (7dI). In gastrocnemius of mice (female C57BL/6J, 10 weeks) exposed to recovery following a seven-day period of hindlimb immobilization with/without curcumin treatment, markers of muscle proteolysis (systemic troponin-I), atrophy signaling pathways and histone deacetylases, protein synthesis, and muscle phenotypic characteristics and function were analyzed. In gastrocnemius of reloading mice compared to unloaded, muscle function, structure, sirtuin-1, and protein synthesis improved, while proteolytic and signaling markers (FoxO1/3) declined. In gastrocnemius of unloaded and reloaded mice treated with curcumin, proteolytic and signaling markers (NF-kB p50) decreased and sirtuin-1 activity and hybrid fibers size increased (reloaded muscle), while no significant improvement was seen in muscle function. Treatment with curcumin elicited a rise in sirtuin-1 activity, while attenuating proteolysis in gastrocnemius of mice during reloading following a period of unloading. Curcumin attenuated muscle proteolysis probably via activation of histone deacetylase sirtuin-1, which also led to decreased levels of atrophy signaling pathways. These findings offer an avenue of research in the design of therapeutic strategies in clinical settings of patients exposed to periods of disuse muscle atrophy. View Full-Text
Keywords: disuse muscle atrophy; muscle reloading; limb muscle; sirtuin-1; curcumin; proteolysis and apoptosis; acetylation of atrophy signaling pathways disuse muscle atrophy; muscle reloading; limb muscle; sirtuin-1; curcumin; proteolysis and apoptosis; acetylation of atrophy signaling pathways
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MDPI and ACS Style

Mañas-García, L.; Bargalló, N.; Gea, J.; Barreiro, E. Muscle Phenotype, Proteolysis, and Atrophy Signaling During Reloading in Mice: Effects of Curcumin on the Gastrocnemius. Nutrients 2020, 12, 388. https://doi.org/10.3390/nu12020388

AMA Style

Mañas-García L, Bargalló N, Gea J, Barreiro E. Muscle Phenotype, Proteolysis, and Atrophy Signaling During Reloading in Mice: Effects of Curcumin on the Gastrocnemius. Nutrients. 2020; 12(2):388. https://doi.org/10.3390/nu12020388

Chicago/Turabian Style

Mañas-García, Laura; Bargalló, Nuria; Gea, Joaquim; Barreiro, Esther. 2020. "Muscle Phenotype, Proteolysis, and Atrophy Signaling During Reloading in Mice: Effects of Curcumin on the Gastrocnemius" Nutrients 12, no. 2: 388. https://doi.org/10.3390/nu12020388

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