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Open AccessArticle

Vitamin D and Abdominal Aortic Calcification in Older African American Women, the PODA Clinical Trial

1
Bone Mineral Research, NYU Winthrop Hospital/NYU Langone Health, Mineola, NY 11501, USA
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Department of Endocrinology, NYU Winthrop Hospital/NYU Langone Health, Mineola, NY 11501, USA
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Biostatistician, NYU Winthrop Research Institute, NYU Long Island School of Medicine, NYU Langone Health, Mineola, NY 11501, USA
*
Author to whom correspondence should be addressed.
Nutrients 2020, 12(3), 861; https://doi.org/10.3390/nu12030861
Received: 28 February 2020 / Revised: 17 March 2020 / Accepted: 20 March 2020 / Published: 24 March 2020
(This article belongs to the Section Clinical Nutrition)
Abdominal aortic calcification (AAC) detected on lateral vertebral fracture assessment is associated with increased cardiovascular risk. Vitamin D deficiency and toxicity have been linked with vascular calcification. The objective of this study was to determine the effect of high-dose vitamin D on the progression of AAC. The Physical Performance, Osteoporosis and vitamin D in African American Women (PODA) is a randomized, clinical trial examining the effect of vitamin D. There were 14.7% subjects with AAC in the vitamin D group, compared to 12.1% in the placebo group at baseline. The prevalence of extended AAC at baseline was 6.4% in the vitamin D group and 3.5% in the placebo group. The extended calcification scores over time were not different between groups. There was no association between AAC and serum 25(OH)D. However, PTH was associated with an increase in AAC in the placebo group. View Full-Text
Keywords: abdominal aortic calcification (AAC); extended aortic calcification (AAC24); chronic kidney disease (CKD); vertebral fracture assessment (VFA); vascular calcification (VC); dual-energy X-ray absorptiometry (DXA); African American (AA); parathyroid hormone abdominal aortic calcification (AAC); extended aortic calcification (AAC24); chronic kidney disease (CKD); vertebral fracture assessment (VFA); vascular calcification (VC); dual-energy X-ray absorptiometry (DXA); African American (AA); parathyroid hormone
MDPI and ACS Style

Brahmbhatt, S.; Mikhail, M.; Islam, S.; Aloia, J.F. Vitamin D and Abdominal Aortic Calcification in Older African American Women, the PODA Clinical Trial. Nutrients 2020, 12, 861.

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