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ADORA2A C Allele Carriers Exhibit Ergogenic Responses to Caffeine Supplementation

Institute for Health and Sport (IHES), Victoria University, Melbourne 3011, Australia
Institute of Coaching and Performance, School of Sport and Wellbeing, University of Central Lancashire, Preston PR1 2HE, UK
School of Medical and Health Sciences, Edith Cowan University, Joondalup, Perth, WA 6027, Australia
Centre for Sport Studies, Rey Juan Carlos University, C/Camino del Molino, s/n, 28943 Fuenlabrada, Spain
Department of Health Sciences, Lehman College, Bronx, NY 10468, USA
Energy Balance & Body Composition Laboratory, Department of Kinesiology & Sport Management, Texas Tech University, Lubbock, TX 79424, USA
Author to whom correspondence should be addressed.
Nutrients 2020, 12(3), 741;
Received: 14 February 2020 / Revised: 3 March 2020 / Accepted: 9 March 2020 / Published: 11 March 2020
(This article belongs to the Section Sports Nutrition)
Caffeine’s ergogenic effects on exercise performance are generally explained by its ability to bind to adenosine receptors. ADORA2A is the gene that encodes A2A subtypes of adenosine receptors. It has been suggested that ADORA2A gene polymorphisms may be responsible for the inter-individual variations in the effects of caffeine on exercise performance. In the only study that explored the influence of variation in ADORA2A—in this case, a common polymorphism (rs5751876)—on the ergogenic effects of caffeine on exercise performance, C allele carriers were identified as “non-responders” to caffeine. To explore if C allele carriers are true “non-responders” to the ergogenic effects of caffeine, in this randomized, double-blind study, we examined the acute effects of caffeine ingestion among a sample consisting exclusively of ADORA2A C allele carriers. Twenty resistance-trained men identified as ADORA2A C allele carriers (CC/CT genotype) were tested on two occasions, following the ingestion of caffeine (3 mg/kg) and a placebo. Exercise performance was evaluated with movement velocity, power output, and muscle endurance during the bench press exercise, countermovement jump height, and power output during a Wingate test. Out of the 25 analyzed variables, caffeine was ergogenic in 21 (effect size range: 0.14 to 0.96). In conclusion, ADORA2A (rs5751876) C allele carriers exhibited ergogenic responses to caffeine ingestion, with the magnitude of improvements similar to what was previously reported in the literature among samples that were not genotype-specific. Therefore, individuals with the CT/CC genotype may still consider supplementing with caffeine for acute improvements in performance. View Full-Text
Keywords: caffeine; ergogenic aid; genetics; mean velocity caffeine; ergogenic aid; genetics; mean velocity
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MDPI and ACS Style

Grgic, J.; Pickering, C.; Bishop, D.J.; Del Coso, J.; Schoenfeld, B.J.; Tinsley, G.M.; Pedisic, Z. ADORA2A C Allele Carriers Exhibit Ergogenic Responses to Caffeine Supplementation. Nutrients 2020, 12, 741.

AMA Style

Grgic J, Pickering C, Bishop DJ, Del Coso J, Schoenfeld BJ, Tinsley GM, Pedisic Z. ADORA2A C Allele Carriers Exhibit Ergogenic Responses to Caffeine Supplementation. Nutrients. 2020; 12(3):741.

Chicago/Turabian Style

Grgic, Jozo, Craig Pickering, David J. Bishop, Juan Del Coso, Brad J. Schoenfeld, Grant M. Tinsley, and Zeljko Pedisic. 2020. "ADORA2A C Allele Carriers Exhibit Ergogenic Responses to Caffeine Supplementation" Nutrients 12, no. 3: 741.

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