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Oxidative Stress Biomarkers, Nut-Related Antioxidants, and Cardiovascular Disease

Graduate Program in Health Sciences (Cardiology), Institute of Cardiology of Rio Grande do Sul/University Foundation of Cardiology (IC/FUC), Princesa Isabel Avenue, 395, Porto Alegre, 90040-371 Rio Grande do Sul, Brazil
HCor Research Institute, Coracao Hospital (IP-HCor), Abílio Soares Street, 250, 04004-05 São Paulo, Brazil
Author to whom correspondence should be addressed.
Nutrients 2020, 12(3), 682;
Received: 31 January 2020 / Revised: 25 February 2020 / Accepted: 2 March 2020 / Published: 3 March 2020
(This article belongs to the Special Issue Dietary Antioxidants for Human Health)
Atherosclerosis is related to fat accumulation in the arterial walls and vascular stiffening, and results in acute coronary syndrome which is commonly associated with acute myocardial infarction. Oxidative stress participates in the pathogenesis of atherosclerosis. Thus, the inclusion of food sources of dietary antioxidants, such as different kinds of nuts, may improve biomarkers related to oxidative stress, contributing to a possible reduction in atherosclerosis progression. This article has briefly highlighted the interaction between oxidative stress, atherosclerosis, and cardiovascular disease, in addition to the effect of the consumption of different nuts and related dietary antioxidants—like polyphenols and vitamin E—on biomarkers of oxidative stress in primary and secondary cardiovascular prevention. Studies in vitro suggest that nuts may exert antioxidant effects by DNA repair mechanisms, lipid peroxidation prevention, modulation of the signaling pathways, and inhibition of the MAPK pathways through the suppression of NF-κB and activation of the Nrf2 pathways. Studies conducted in animal models showed the ability of dietary nuts in improving biomarkers of oxidative stress, such as oxLDL and GPx. However, clinical trials in humans have not been conclusive, especially with regards to the secondary prevention of cardiovascular disease. View Full-Text
Keywords: oxidative stress; antioxidants; nuts; cardiovascular diseases oxidative stress; antioxidants; nuts; cardiovascular diseases
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MDPI and ACS Style

Lorenzon dos Santos, J.; Schaan de Quadros, A.; Weschenfelder, C.; Bueno Garofallo, S.; Marcadenti, A. Oxidative Stress Biomarkers, Nut-Related Antioxidants, and Cardiovascular Disease. Nutrients 2020, 12, 682.

AMA Style

Lorenzon dos Santos J, Schaan de Quadros A, Weschenfelder C, Bueno Garofallo S, Marcadenti A. Oxidative Stress Biomarkers, Nut-Related Antioxidants, and Cardiovascular Disease. Nutrients. 2020; 12(3):682.

Chicago/Turabian Style

Lorenzon dos Santos, Julia; Schaan de Quadros, Alexandre; Weschenfelder, Camila; Bueno Garofallo, Silvia; Marcadenti, Aline. 2020. "Oxidative Stress Biomarkers, Nut-Related Antioxidants, and Cardiovascular Disease" Nutrients 12, no. 3: 682.

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