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Open AccessArticle

Oral Microbiota Profile Associates with Sugar Intake and Taste Preference Genes

1
Department of Odontology/Section of Cariology, Umeå University, 901 87 Umeå, Sweden
2
Medical Research Council Integrative Epidemiology Unit, Department of Population Health Sciences Bristol Medical School, University of Bristol, Bristol BS8 2BN, UK
3
Bristol Dental School, University of Bristol, Bristol BS1 2LY, UK
4
Department of Odontology/Section of Pediatric Dentistry, Umeå University, 901 87 Umeå, Sweden
*
Author to whom correspondence should be addressed.
Nutrients 2020, 12(3), 681; https://doi.org/10.3390/nu12030681
Received: 31 January 2020 / Revised: 25 February 2020 / Accepted: 28 February 2020 / Published: 3 March 2020
(This article belongs to the Section Nutritional Epidemiology)
Oral microbiota ecology is influenced by environmental and host conditions, but few studies have evaluated associations between untargeted measures of the entire oral microbiome and potentially relevant environmental and host factors. This study aimed to identify salivary microbiota cluster groups using hierarchical cluster analyses (Wards method) based on 16S rRNA gene amplicon sequencing, and identify lifestyle and host factors which were associated with these groups. Group members (n = 175) were distinctly separated by microbiota profiles and differed in reported sucrose intake and allelic variation in the taste-preference-associated genes TAS1R1 (rs731024) and GNAT3 (rs2074673). Groups with higher sucrose intake were either characterized by a wide panel of species or phylotypes with fewer aciduric species, or by a narrower profile that included documented aciduric- and caries-associated species. The inferred functional profiles of the latter type were dominated by metabolic pathways associated with the carbohydrate metabolism with enrichment of glycosidase functions. In conclusion, this study supported in vivo associations between sugar intake and oral microbiota ecology, but it also found evidence for a variable microbiota response to sugar, highlighting the importance of modifying host factors and microbes beyond the commonly targeted acidogenic and acid-tolerant species. The results should be confirmed under controlled settings with comprehensive phenotypic and genotypic data. View Full-Text
Keywords: microbiota; saliva; sugar; taste; genes; 16S rDNA sequencing microbiota; saliva; sugar; taste; genes; 16S rDNA sequencing
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MDPI and ACS Style

Esberg, A.; Haworth, S.; Hasslöf, P.; Lif Holgerson, P.; Johansson, I. Oral Microbiota Profile Associates with Sugar Intake and Taste Preference Genes. Nutrients 2020, 12, 681. https://doi.org/10.3390/nu12030681

AMA Style

Esberg A, Haworth S, Hasslöf P, Lif Holgerson P, Johansson I. Oral Microbiota Profile Associates with Sugar Intake and Taste Preference Genes. Nutrients. 2020; 12(3):681. https://doi.org/10.3390/nu12030681

Chicago/Turabian Style

Esberg, Anders; Haworth, Simon; Hasslöf, Pamela; Lif Holgerson, Pernilla; Johansson, Ingegerd. 2020. "Oral Microbiota Profile Associates with Sugar Intake and Taste Preference Genes" Nutrients 12, no. 3: 681. https://doi.org/10.3390/nu12030681

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