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Open AccessArticle

Effects of Timing of Acute and Consecutive Catechin Ingestion on Postprandial Glucose Metabolism in Mice and Humans

Organization for University Research Initiatives, Waseda University, 2-2 Wakamatsu-cho, Shinjuku, Tokyo 1628480, Japan
Graduate School of Advanced Science and Engineering, Waseda University, 2-2 Wakamatsu-cho Shinjuku, Tokyo 1628480, Japan
Faculty of Science and Engineering, Waseda Univesity, 2-2 Wakamatsu-cho, Shinjuku, Tokyo 1628480, Japan
AIST-National Institute of Advanced Industrial Science and Technology, Waseda University Computational Bio Big-Data Open Innovation Laboratory (CBBD-OIL), Tokyo 1690072, Japan
R&D, Core Technology, Biological Science Research, Kao Corporation, 2-1-3 Bunka Sumida, Tokyo 1318501, Japan
Faculty of Sport Sciences, Waseda University, 2-579-15 Mikajima Tokorozawa, Saitama 3591192, Japan
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Nutrients 2020, 12(2), 565;
Received: 26 December 2019 / Revised: 14 February 2020 / Accepted: 18 February 2020 / Published: 21 February 2020
(This article belongs to the Special Issue Meal Timing to Improve Human Health)
We examined the effects of the timing of acute and consecutive epigallocatechin gallate (EGCG) and catechin-rich green tea ingestion on postprandial glucose in mice and human adults. In mouse experiments, we compared the effects of EGCG administration early (morning) and late (evening) in the active period on postprandial glucose. In human experiments, participants were randomly assigned to the morning-placebo (MP, n = 10), morning-green tea (MGT, n = 10), evening-placebo (EP, n = 9), and evening-green tea (EGT, n = 9) groups, and consumed either catechin-rich green tea or a placebo beverage for 1 week. At baseline and after 1 week, participants consumed their designated beverages with breakfast (MP and MGT) or supper (EP and EGT). Venous blood samples were collected in the fasted state and 30, 60, 120, and 180 min after each meal. Consecutive administration of EGCG in the evening, but not in the morning, reduced postprandial glucose at 30 (p = 0.006) and 60 (p = 0.037) min in the evening trials in mice. In humans, ingestion of catechin-rich green tea in the evening decreased postprandial glucose (three-factor analysis of variance, p < 0.05). Thus, catechin intake in the evening more effectively suppressed elevation of postprandial glucose. View Full-Text
Keywords: glucose metabolism; epigallocatechin gallate; green tea; insulin; timing glucose metabolism; epigallocatechin gallate; green tea; insulin; timing
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Takahashi, M.; Ozaki, M.; Tsubosaka, M.; Kim, H.-K.; Sasaki, H.; Matsui, Y.; Hibi, M.; Osaki, N.; Miyashita, M.; Shibata, S. Effects of Timing of Acute and Consecutive Catechin Ingestion on Postprandial Glucose Metabolism in Mice and Humans. Nutrients 2020, 12, 565.

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