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Open AccessArticle

Effects of Coriandrum sativum Seed Extract on Aging-Induced Memory Impairment in Samp8 Mice

1
General Health Medical Center, Yokohama University of Pharmacy, Kanagawa 245-0066, Japan
2
School of Nutrition and Health Sciences, Taipei Medical University, Taipei 11031, Taiwan
3
Research Center of Geriatric Nutrition, College of Nutrition, Taipei Medical University, Taipei 11031, Taiwan
4
Nutrition Research Center, Taipei Medical University Hospital, Taipei 11031, Taiwan
*
Authors to whom correspondence should be addressed.
Nutrients 2020, 12(2), 455; https://doi.org/10.3390/nu12020455
Received: 25 November 2019 / Revised: 21 January 2020 / Accepted: 5 February 2020 / Published: 11 February 2020
(This article belongs to the Section Phytochemicals and Human Health)
The purpose of this study was to investigate whether or not Coriandrum sativum seed extract (CSSE) can ameliorate memory impairment in senescence-accelerated mouse-prone 8 (SAMP8) mice. Sixteen 10-week-old male SAMP8 mice were divided into two groups, which were orally administrated water (SAMP8(−)) or CSSE (200 mg/kg/day; SAMP8(+)). Eight 10-week-old male Institute of Cancer Research (ICR) mice were used as a normal control group and were also orally administrated water. The mean escape time in the Barnes maze test of SAMP8(−) mice was significantly longer than that of ICR mice. However, SAMP8(+) mice showed a shorter mean escape time compared to that of SAMP8(−) mice. Neurofilament messenger (m)RNA levels significantly decreased in the frontal lobe of SAMP8(−) mice when compared with ICR mice, but significantly increased in SAMP8(+) mice relative to SAMP8(−) mice. In addition, mRNA levels of inducible nitric oxide synthase (iNOS) and neuronal (n)NOS significantly increased in the frontal lobe of SAMP8(−) mice, but only the mRNA level of nNOS significantly decreased in SAMP8(+) mice. These results indicated that continuous oral administration of CSSE for 12 weeks could ameliorate aging-induced memory declines in the senescence-accelerated SAMP8 mouse model.
Keywords: Coriandrum sativum seed extract; memory impairment; senescence-accelerated mouse-prone 8 (SAMP8) mice Coriandrum sativum seed extract; memory impairment; senescence-accelerated mouse-prone 8 (SAMP8) mice
MDPI and ACS Style

Mima, Y.; Izumo, N.; Chen, J.-R.; Yang, S.-C.; Furukawa, M.; Watanabe, Y. Effects of Coriandrum sativum Seed Extract on Aging-Induced Memory Impairment in Samp8 Mice. Nutrients 2020, 12, 455.

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