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Open AccessArticle

Fucose Ameliorates Tryptophan Metabolism and Behavioral Abnormalities in a Mouse Model of Chronic Colitis

1
The Federal Research Center Institute of Cytology and Genetics of The Siberian Branch of the Russian Academy of Sciences, 630090 Novosibirsk, Russia
2
International Tomography Center, The Siberian Branch of the Russian Academy of Sciences, 630090 Novosibirsk, Russia
3
Novosibirsk State University, Department of natural sciences, 630090 Novosibirsk, Russia
4
Scientific Research Institute of Physiology and Basic Medicine, 630117 Novosibirsk, Russia
5
Siberian Federal Scientific Centre of Agro-BioTechnologies of the Russian Academy of Sciences, Krasnoobsk, 630501 Novosibirsk, Russia
6
Institute of Molecular and Cellular Biology, The Siberian Branch of the Russian Academy of Sciences, 630090 Novosibirsk, Russia
*
Author to whom correspondence should be addressed.
Nutrients 2020, 12(2), 445; https://doi.org/10.3390/nu12020445
Received: 21 January 2020 / Revised: 31 January 2020 / Accepted: 7 February 2020 / Published: 11 February 2020
(This article belongs to the Special Issue Role of Prebiotics and Probiotics in Health and Disease)
Growing evidence suggests that intestinal mucosa homeostasis impacts immunity, metabolism, the Central Nervous System (CNS), and behavior. Here, we investigated the effect of the monosaccharide fucose on inflammation, metabolism, intestinal microbiota, and social behavior in the Dextran Sulfate Sodium (DSS)-induced chronic colitis mouse model. Our data show that chronic colitis is accompanied by the decrease of the serum tryptophan level and the depletion of the intestinal microbiota, specifically tryptophan-producing E. coli and Bifidobacterium. These changes are associated with defects in the male mouse social behavior such as a lack of preference towards female bedding in an odor preference test. The addition of fucose to the test animals’ diet altered the bacterial community, increased the abundance of tryptophan-producing E. coli, normalized blood tryptophan levels, and ameliorated social behavior deficits. At the same time, we observed no ameliorating effect of fucose on colon morphology and colitis. Our results suggest a possible mechanism by which intestinal inflammation affects social behavior in male mice. We propose fucose as a promising prebiotic, since it creates a favorable environment for the beneficial bacteria that promote normalization of serum tryptophan level and amelioration of the behavioral abnormalities in the odor preference test.
Keywords: DSS-induced colitis; inflammation; microbiota; odor preference; fucose; tryptophan DSS-induced colitis; inflammation; microbiota; odor preference; fucose; tryptophan
MDPI and ACS Style

Borisova, M.A.; Snytnikova, O.A.; Litvinova, E.A.; Achasova, K.M.; Babochkina, T.I.; Pindyurin, A.V.; Tsentalovich, Y.P.; Kozhevnikova, E.N. Fucose Ameliorates Tryptophan Metabolism and Behavioral Abnormalities in a Mouse Model of Chronic Colitis. Nutrients 2020, 12, 445.

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