Postbiotics for Preventing and Treating Common Infectious Diseases in Children: A Systematic Review
1
Doctorado en Salud Pública, Facultad de Medicina, Universidad El Bosque, 110121 Bogota, Colombia
2
Instituto Nacional de Salud de Colombia, 111321 Bogota, Colombia
3
Functional Foods Forum, Faculty of Medicine, University of Turku, 20520 Turku, Finland
4
Department of Paediatrics at the Medical University of Warsaw, 02091 Warsaw, Poland
*
Author to whom correspondence should be addressed.
Nutrients 2020, 12(2), 389; https://doi.org/10.3390/nu12020389
Received: 19 December 2019
/
Revised: 18 January 2020
/
Accepted: 28 January 2020
/
Published: 31 January 2020
(This article belongs to the Section Nutrition and Public Health)
Postbiotics have recently been tentatively defined as bioactive compounds produced during a fermentation process (including microbial cells, cell constituents and metabolites) that supports health and/or wellbeing. Postbiotics are currently available in some infant formulas and fermented foods. We systematically reviewed evidence on postbiotics for preventing and treating common infectious diseases among children younger than 5 years. The PubMed, Embase, SpringerLink, and ScienceDirect databases were searched up to March 2019 for randomized controlled trials (RCTs) comparing postbiotics with placebo or no intervention. Seven RCTs involving 1740 children met the inclusion criteria. For therapeutic trials, supplementation with heat-killed Lactobacillus acidophilus LB reduced the duration of diarrhea (4 RCTs, n = 224, mean difference, MD, −20.31 h, 95% CI −27.06 to −13.57). For preventive trials, the pooled results from two RCTs (n = 537) showed that heat-inactivated L. paracasei CBA L74 versus placebo reduced the risk of diarrhea (relative risk, RR, 0.51, 95% CI 0.37–0.71), pharyngitis (RR 0.31, 95% CI 0.12–0.83) and laryngitis (RR 0.44, 95% CI 0.29–0.67). There is limited evidence to recommend the use of specific postbiotics for treating pediatric diarrhea and preventing common infectious diseases among children. Further studies are necessary to determine the effects of different postbiotics.
View Full-Text
▼
Show Figures
Figure 1
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
MDPI and ACS Style
Malagón-Rojas, J.N.; Mantziari, A.; Salminen, S.; Szajewska, H. Postbiotics for Preventing and Treating Common Infectious Diseases in Children: A Systematic Review. Nutrients 2020, 12, 389. https://doi.org/10.3390/nu12020389
AMA Style
Malagón-Rojas JN, Mantziari A, Salminen S, Szajewska H. Postbiotics for Preventing and Treating Common Infectious Diseases in Children: A Systematic Review. Nutrients. 2020; 12(2):389. https://doi.org/10.3390/nu12020389
Chicago/Turabian StyleMalagón-Rojas, Jeadran N., Anastasia Mantziari, Seppo Salminen, and Hania Szajewska. 2020. "Postbiotics for Preventing and Treating Common Infectious Diseases in Children: A Systematic Review" Nutrients 12, no. 2: 389. https://doi.org/10.3390/nu12020389
Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.
