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Article

A Randomized, Double-Blind, Placebo-Controlled Clinical Trial Assessing the Effects of Angelica Gigas Nakai Extract on Blood Triglycerides

by 1,2,†, 1,3,†, 1, 3, 4 and 1,2,5,*
1
Clinical Trial Center for Functional Foods, Chonbuk National University Hospital, Jeonju, Jeonbuk 54907, Korea
2
Biomedical Research Institute, Chonbuk National University Hospital, Jeonju, Jeonbuk 54907, Korea
3
Department of Food Science and Human Nutrition, Chonbuk National University, Jeonju, Jeonbuk 54896, Korea
4
Department of Biochemistry and Molecular Biology, Chonbuk National University Medical School Jeonju, Jeonbuk 54896, Korea
5
Department of Pharmacology, Chonbuk National University Medical School, Jeonju, Jeonbuk 54896, Korea
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work as first authors.
Nutrients 2020, 12(2), 377; https://doi.org/10.3390/nu12020377
Received: 21 December 2019 / Revised: 26 January 2020 / Accepted: 28 January 2020 / Published: 31 January 2020
(This article belongs to the Special Issue Benefits of Dietary Phytochemicals)
Angelica gigas Nakai, Korean dang-gui, has long been widely used in traditional treatment methods. There have been a number of studies of the health effects of A. gigas and related compounds, but studies addressing effects on blood triglycerides (TG) are lacking. To investigate the effects of A. gigas Nakai extract (AGNE) on TG in Korean subjects, we carried out a 12-week, randomized, double-blind, placebo-controlled clinical trial. Subjects who met the inclusion criterion (130 mg/dL ≤ fasting blood TG ≤ 200 mg/dL) were recruited for this study. One hundred subjects were assigned to the AGNE group (n = 50) or the placebo group (n = 50), who were given 1 g/day of AGNE (as a gigas Nakai extract 200 mg/d) in capsules and the control group for 12 weeks. Outcomes were efficacy TG, lipid profiles, atherogenic index, and safety parameters were assessed initially for a baseline measurement and after 12 weeks. After 12 weeks of supplementation, TG and very low-density lipoprotein cholesterol (VLDL-C) concentration and TG/HDL-C ratio in the AGNE group were significantly reduced compared to the placebo group (p < 05). No significant changes in any safety parameter were observed. These results suggest that the ingestion of AGNE may improve TG and be useful to manage or prevent hypertriglyceridemia. View Full-Text
Keywords: Angelica gigas Nakai; triglycerides; VLDL-C; TG/HDL-C; atherogenic index Angelica gigas Nakai; triglycerides; VLDL-C; TG/HDL-C; atherogenic index
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MDPI and ACS Style

Jung, S.-J.; Kim, W.-R.; Oh, M.-R.; Cha, Y.-S.; Park, B.-H.; Chae, S.-W. A Randomized, Double-Blind, Placebo-Controlled Clinical Trial Assessing the Effects of Angelica Gigas Nakai Extract on Blood Triglycerides. Nutrients 2020, 12, 377. https://doi.org/10.3390/nu12020377

AMA Style

Jung S-J, Kim W-R, Oh M-R, Cha Y-S, Park B-H, Chae S-W. A Randomized, Double-Blind, Placebo-Controlled Clinical Trial Assessing the Effects of Angelica Gigas Nakai Extract on Blood Triglycerides. Nutrients. 2020; 12(2):377. https://doi.org/10.3390/nu12020377

Chicago/Turabian Style

Jung, Su-Jin, Woo-Rim Kim, Mi-Ra Oh, Youn-Soo Cha, Byung-Hyun Park, and Soo-Wan Chae. 2020. "A Randomized, Double-Blind, Placebo-Controlled Clinical Trial Assessing the Effects of Angelica Gigas Nakai Extract on Blood Triglycerides" Nutrients 12, no. 2: 377. https://doi.org/10.3390/nu12020377

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