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Open AccessReview

Nutraceuticals and Hypertensive Disorders in Pregnancy: The Available Clinical Evidence

1
Medical and Surgical Sciences Department, Sant’Orsola-Malpighi University Hospital, Building 2-IV Floor, Via Albertoni 15, 40138 Bologna, Italy
2
Italian Nutraceutical Society (SINut), Via Guelfa 9, 40138 Bologna, Italy
*
Author to whom correspondence should be addressed.
Nutrients 2020, 12(2), 378; https://doi.org/10.3390/nu12020378
Received: 30 November 2019 / Revised: 28 January 2020 / Accepted: 29 January 2020 / Published: 31 January 2020
The aim of the present critical review is to summarize the available clinical evidence supporting the use of some dietary supplements that have been shown to lower blood pressure in hypertensive pregnant women. A systematic search strategy was carried out to identify trials in MEDLINE (National Library of Medicine, Bethesda, Maryland, MD, USA; January 1980 to September 2019) and the Cochrane Register of Controlled Trials (The Cochrane Collaboration, Oxford, UK). The terms ‘nutraceuticals’, ‘dietary supplements’, ‘pregnancy’, ‘pre-eclampsia’, ‘clinical trial’, and ‘human’ were incorporated into an electronic search strategy. The references of the identified studies and review articles were reviewed to look for additional studies of interest. We preferably selected papers that reported recent comprehensive reviews or meta-analysis, or original clinical trials of substances with blood pressure-lowering or vascular protective effect in pregnancy. There is a relative body of evidence that supports the use of calcium, vitamin D, folic acid, and resveratrol in preventing the development of hypertensive disorders in pregnancy, and evidence supporting drug treatment too. Further clinical research is advisable to identify the dosage and timing of the supplementation, the group of women that might benefit the most from this approach, and the nutraceuticals with the best cost-effectiveness and risk-benefit ratio for widespread use in clinical practice. View Full-Text
Keywords: pregnancy; hypertension; hypertensive disorders; pre-eclampsia pregnancy; hypertension; hypertensive disorders; pre-eclampsia
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Fogacci, S.; Fogacci, F.; Cicero, A.F. Nutraceuticals and Hypertensive Disorders in Pregnancy: The Available Clinical Evidence. Nutrients 2020, 12, 378.

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