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Review

Health-Promoting Properties of Proanthocyanidins for Intestinal Dysfunction

MoBioFood Research Group, Departament de Bioquímica i Biotecnologia, Universitat Rovira i Virgili, 43007 Tarragona, Spain
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Nutrients 2020, 12(1), 130; https://doi.org/10.3390/nu12010130
Received: 5 December 2019 / Revised: 20 December 2019 / Accepted: 31 December 2019 / Published: 2 January 2020
(This article belongs to the Special Issue Benefits of Dietary Phytochemicals)
The intestinal barrier is constantly exposed to potentially harmful environmental factors, including food components and bacterial endotoxins. When intestinal barrier function and immune homeostasis are compromised (intestinal dysfunction), inflammatory conditions may develop and impact overall health. Evidence from experimental animal and cell culture studies suggests that exposure of intestinal mucosa to proanthocyanidin (PAC)-rich plant products, such as grape seeds, may contribute to maintaining the barrier function and to ameliorating the pathological inflammation present in diet-induced obesity and inflammatory bowel disease. In this review, we aim to update the current knowledge on the bioactivity of PACs in experimental models of intestinal dysfunction and in humans, and to provide insights into the underlying biochemical and molecular mechanisms. View Full-Text
Keywords: gut; permeability; inflammation; metabolic endotoxemia; obesity; IBD; flavonoid; flavan-3-ol; condensed tannin; procyanidin gut; permeability; inflammation; metabolic endotoxemia; obesity; IBD; flavonoid; flavan-3-ol; condensed tannin; procyanidin
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MDPI and ACS Style

González-Quilen, C.; Rodríguez-Gallego, E.; Beltrán-Debón, R.; Pinent, M.; Ardévol, A.; Blay, M.T.; Terra, X. Health-Promoting Properties of Proanthocyanidins for Intestinal Dysfunction. Nutrients 2020, 12, 130. https://doi.org/10.3390/nu12010130

AMA Style

González-Quilen C, Rodríguez-Gallego E, Beltrán-Debón R, Pinent M, Ardévol A, Blay MT, Terra X. Health-Promoting Properties of Proanthocyanidins for Intestinal Dysfunction. Nutrients. 2020; 12(1):130. https://doi.org/10.3390/nu12010130

Chicago/Turabian Style

González-Quilen, Carlos, Esther Rodríguez-Gallego, Raúl Beltrán-Debón, Montserrat Pinent, Anna Ardévol, M T. Blay, and Ximena Terra. 2020. "Health-Promoting Properties of Proanthocyanidins for Intestinal Dysfunction" Nutrients 12, no. 1: 130. https://doi.org/10.3390/nu12010130

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