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Article

Effects of Daily Raspberry Consumption on Immune-Metabolic Health in Subjects at Risk of Metabolic Syndrome: A Randomized Controlled Trial

1
Centre Nutrition, Santé et Société (NUTRISS) and Institut sur la Nutrition et les Aliments Fonctionnels (INAF), Université Laval, Québec, QC G1V 0A6, Canada
2
School of Nutrition, Université Laval, Québec, QC G1V 0A6, Canada
3
Quebec Heart and Lung Institute (IUCPQ) Research Center, 2725 Chemin Sainte-Foy, Québec, QC G1V 4G5, Canada
4
Endocrinology and Nephrology Unit, CHU de Québec-Université Laval, Québec, QC G1V 4G2, Canada
*
Author to whom correspondence should be addressed.
Nutrients 2020, 12(12), 3858; https://doi.org/10.3390/nu12123858
Received: 17 November 2020 / Revised: 2 December 2020 / Accepted: 15 December 2020 / Published: 17 December 2020
(This article belongs to the Special Issue Nutrigenomics and the Future of Nutrition)
Consumption of red raspberries has been reported to exert acute beneficial effects on postprandial glycemia, insulinemia, triglyceridemia, and cytokine levels in metabolically disturbed subjects. In a two-arm parallel-group, randomized, controlled trial, 59 subjects with overweight or abdominal obesity and with slight hyperinsulinemia or hypertriglyceridemia were randomized to consume 280 g/day of frozen raspberries or to maintain their usual diet for 8 weeks. Primary analyses measured metabolic differences between the groups. Secondary analyses performed with omics tools in the intervention group assessed blood gene expression and plasma metabolomic changes following the raspberry supplementation. The intervention did not significantly affect plasma insulin, glucose, inflammatory marker concentrations, nor blood pressure. Following the supplementation, 43 genes were differentially expressed, and several functional pathways were enriched, a major portion of which were involved in the regulation of cytotoxicity, immune cell trafficking, protein signal transduction, and interleukin production. In addition, 10 serum metabolites were found significantly altered, among which β-alanine, trimethylamine N-oxide, and bioactive lipids. Although the supplementation had no meaningful metabolic effects, these results highlight the impact of a diet rich in raspberry on the immune function and phospholipid metabolism, thus providing novel insights into potential immune-metabolic pathways influenced by regular raspberry consumption. View Full-Text
Keywords: berry fruits; metabolic syndrome; multi-omics; immunity; gene expression; sphingolipids; phenolic compounds berry fruits; metabolic syndrome; multi-omics; immunity; gene expression; sphingolipids; phenolic compounds
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MDPI and ACS Style

Franck, M.; de Toro-Martín, J.; Garneau, V.; Guay, V.; Kearney, M.; Pilon, G.; Roy, D.; Couture, P.; Couillard, C.; Marette, A.; Vohl, M.-C. Effects of Daily Raspberry Consumption on Immune-Metabolic Health in Subjects at Risk of Metabolic Syndrome: A Randomized Controlled Trial. Nutrients 2020, 12, 3858. https://doi.org/10.3390/nu12123858

AMA Style

Franck M, de Toro-Martín J, Garneau V, Guay V, Kearney M, Pilon G, Roy D, Couture P, Couillard C, Marette A, Vohl M-C. Effects of Daily Raspberry Consumption on Immune-Metabolic Health in Subjects at Risk of Metabolic Syndrome: A Randomized Controlled Trial. Nutrients. 2020; 12(12):3858. https://doi.org/10.3390/nu12123858

Chicago/Turabian Style

Franck, Maximilien, Juan de Toro-Martín, Véronique Garneau, Valérie Guay, Michèle Kearney, Geneviève Pilon, Denis Roy, Patrick Couture, Charles Couillard, André Marette, and Marie-Claude Vohl. 2020. "Effects of Daily Raspberry Consumption on Immune-Metabolic Health in Subjects at Risk of Metabolic Syndrome: A Randomized Controlled Trial" Nutrients 12, no. 12: 3858. https://doi.org/10.3390/nu12123858

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