No Influence of the Fat Mass and Obesity-Associated Gene rs9939609 Single Nucleotide Polymorphism on Blood Lipids in Young Males
Abstract
:1. Introduction
2. Materials and Methods
2.1. Participants
2.2. Preliminary Measures
2.3. Experimental Procedure
2.4. Blood Sampling
2.5. Biochemical Analysis
2.6. Statistical Analyses
3. Results
3.1. Participant Characteristics
3.2. Blood Markers
3.3. Retrospective Power Calculations
4. Discussion
5. Conclusions
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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AA (n =12) | TT (n = 12) | TT vs. AA Mean Difference (95% CI 1) | |
---|---|---|---|
Age (year) | 20.9 ± 3.5 | 21.3 ± 3.6 | −0.4 (−3.4 to 2.6) |
Height (cm) | 181.6 ± 5.8 | 177.5 ± 6.5 | 4.1 (−1.2 to 9.3) |
Weight (kg) | 77.6 ± 11.3 | 73.8 ± 6.9 | 3.9 (−4.1 to 11.8) |
Body mass index (kg/m2) | 23.5 ± 2.7 | 23.5 ± 2.3 | 0.0 (−2.1 to 2.1) |
Waist circumference (cm) | 80.3 ± 6.1 | 78.1 ± 4.1 | 2.2 (−2.2 to 6.6) |
Body fat percentage (%) | 15.6 ± 5.1 | 13.9 ± 4.7 | 1.7 (−2.4 to 5.9) |
Lean body mass (kg) | 65.2 ± 7.4 | 63.3 ± 4.2 | 1.9 (−3.2 to 7.0) |
Peak oxygen uptake (mL/kg/minute) | 55.8 ± 5.8 | 56.6 ± 4.9 | −0.8 (−5.4 to 3.7) |
Physical activity (metabolic equivalent minutes/week) | 4368 ± 1968 | 4790 ± 2728 | −423 (−2436 to 1591) |
AA (n = 12) | TT (n = 12) | TT Vs. AA Mean Difference (95% CI 1) | Effect Size | |
---|---|---|---|---|
Triacylglycerol (mmol/L) | ||||
Baseline | 0.77 ± 0.08 | 0.88 ± 0.07 | −0.11 (−0.32 to 0.10) | 0.44 |
Pre-meal | 0.74 ± 0.08 | 0.81 ± 0.07 | −0.07 (−0.28 to 0.14) | 0.28 |
Non-esterified fatty acids (mmol/L) | ||||
Baseline | 0.46 ± 0.09 | 0.43 ± 0.06 | 0.03 (−0.18 to 0.25) | 0.12 |
Pre-meal | 0.41 ± 0.06 | 0.45 ± 0.06 | −0.03 (−0.21 to 0.14) | 0.16 |
Total cholesterol (mmol/L) | ||||
Baseline | 3.40 ± 0.12 | 3.41 ± 0.18 | −0.01 (−0.47 to 0.45) | 0.02 |
Low-density lipoprotein cholesterol (mmol/L) | ||||
Baseline | 1.77 ± 0.12 | 1.83 ± 0.14 | −0.07 (−0.45 to 0.32) | 0.15 |
High-density lipoprotein cholesterol (mmol/L) | ||||
Baseline | 1.28 ± 0.07 | 1.24 ± 0.11 | 0.05 (−0.22 to 0.31) | 0.15 |
Glucose (mmol/L) | ||||
Baseline | 5.35 ± 0.11 | 5.26 ± 0.06 | 0.09 (−0.17 to 0.35) | 0.30 |
Pre-meal | 5.18 ± 0.08 | 5.15 ± 0.04 | 0.03 (−0.16 to 0.23) | 0.14 |
Insulin (pmol/L) | ||||
Baseline | 3.34 ± 0.47 | 3.09 ± 0.52 | 0.25 (−1.21 to 1.72) | 0.15 |
Pre-meal | 2.82 ± 0.34 | 3.26 ± 0.55 | −0.44 (−1.76 to 0.89) | 0.28 |
HOMA-IR | ||||
Baseline | 0.81 ± 0.12 | 0.72 ± 0.12 | 0.08 (−0.27 to 0.44) | 0.20 |
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Dorling, J.L.; Thackray, A.E.; King, J.A.; Pucci, A.; Goltz, F.R.; Batterham, R.L.; Stensel, D.J. No Influence of the Fat Mass and Obesity-Associated Gene rs9939609 Single Nucleotide Polymorphism on Blood Lipids in Young Males. Nutrients 2020, 12, 3857. https://doi.org/10.3390/nu12123857
Dorling JL, Thackray AE, King JA, Pucci A, Goltz FR, Batterham RL, Stensel DJ. No Influence of the Fat Mass and Obesity-Associated Gene rs9939609 Single Nucleotide Polymorphism on Blood Lipids in Young Males. Nutrients. 2020; 12(12):3857. https://doi.org/10.3390/nu12123857
Chicago/Turabian StyleDorling, James L., Alice E. Thackray, James A. King, Andrea Pucci, Fernanda R. Goltz, Rachel L. Batterham, and David J. Stensel. 2020. "No Influence of the Fat Mass and Obesity-Associated Gene rs9939609 Single Nucleotide Polymorphism on Blood Lipids in Young Males" Nutrients 12, no. 12: 3857. https://doi.org/10.3390/nu12123857