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Article

Possible Reduction of Cardiac Risk after Supplementation with Epigallocatechin Gallate and Increase of Ketone Bodies in the Blood in Patients with Multiple Sclerosis. A Pilot Study

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Department of Nursing, Catholic University of Valencia San Vicente Mártir, C/Espartero, 7, 46007 Valencia, Spain
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Doctoral Degree School, Catholic University of Valencia San Vicente Mártir, C/Quevedo, 2, 46001 Valencia, Spain
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Department of Basic Sciences, Catholic University of Valencia San Vicente Mártir, C/Ramiro de Maeztu, 14, 46900 Torrente, Valencia, Spain
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Department of Nutrition and Dietetics, Catholic University of Valencia San Vicente Mártir, C/Quevedo, 2, 46001 Valencia, Spain
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Department of Nursing, Physiotherapy and Medicine, University of Almería, Carretera Sacramento, C/San Urbano, s/n, La Cañada, 04120 Almería, Spain
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Interdisciplinary Laboratory of Clinical Analysis, Campus of Excellence Mare Nostrum, University of Murcia, 30100 Murcia, Spain
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Authors to whom correspondence should be addressed.
Nutrients 2020, 12(12), 3792; https://doi.org/10.3390/nu12123792
Received: 4 November 2020 / Revised: 4 December 2020 / Accepted: 7 December 2020 / Published: 10 December 2020
(This article belongs to the Special Issue Nutrition Intervention and Cardiovascular Disease)
Multiple sclerosis (MS) is a neurodegenerative disease that causes anthropometric changes characterised by functional disability, increase in fat mass, and decrease in lean mass. All these variables are related to a greater cardiac risk. The polyphenol epigallocatechin gallate (EGCG) and an increase in ketone bodies in the blood have been shown to have beneficial effects on anthropometric and biochemical variables related to cardiovascular activity. The aim of this study was to analyse the impact of the intervention with EGCG and ketone bodies on cardiac risk in MS patients. A population of 51 MS patients were randomly assigned to a control group and an intervention group (daily dose of 800 mg of EGCG and 60 mL of coconut oil). Both groups followed an isocaloric diet for 4 months. Levels of beta-hydroxybutyrate (BHB), albumin, paraoxonase 1 (PON1) and C-reactive protein (CRP) were measured in serum before and after the intervention, as well as determining functional ability, waist circumference, waist-to-hip ratio (WHR), waist-to-height ratio (WHtR), fat percentage and muscle percentage. After 4 months, in the intervention group there was a significant increase in BHB, PON1 and albumin, while CRP did not vary; a significant decrease in cardiac risk associated with a significant decline in WHR; as well as a significant increase in muscle percentage. By contrast, these changes were not observed in the control group. Finally, results from analysis of variance (ANOVA) revealed a significant time–condition interaction effect, observing that WHtR and fat mass decreased in the intervention group, while they increased in the control group. View Full-Text
Keywords: multiple sclerosis; cardiac risk; epigallocatechin gallate; ketone bodies multiple sclerosis; cardiac risk; epigallocatechin gallate; ketone bodies
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MDPI and ACS Style

Benlloch, M.; Cuerda Ballester, M.; Drehmer, E.; Platero, J.L.; Carrera-Juliá, S.; López-Rodríguez, M.M.; Ceron, J.J.; Tvarijonaviciute, A.; Navarro, M.Á.; Moreno, M.L.; de la Rubia Ortí, J.E. Possible Reduction of Cardiac Risk after Supplementation with Epigallocatechin Gallate and Increase of Ketone Bodies in the Blood in Patients with Multiple Sclerosis. A Pilot Study. Nutrients 2020, 12, 3792. https://doi.org/10.3390/nu12123792

AMA Style

Benlloch M, Cuerda Ballester M, Drehmer E, Platero JL, Carrera-Juliá S, López-Rodríguez MM, Ceron JJ, Tvarijonaviciute A, Navarro MÁ, Moreno ML, de la Rubia Ortí JE. Possible Reduction of Cardiac Risk after Supplementation with Epigallocatechin Gallate and Increase of Ketone Bodies in the Blood in Patients with Multiple Sclerosis. A Pilot Study. Nutrients. 2020; 12(12):3792. https://doi.org/10.3390/nu12123792

Chicago/Turabian Style

Benlloch, María, María Cuerda Ballester, Eraci Drehmer, Jose L. Platero, Sandra Carrera-Juliá, María M. López-Rodríguez, Jose J. Ceron, Asta Tvarijonaviciute, Marí Á. Navarro, Mari L. Moreno, and Jose E. de la Rubia Ortí. 2020. "Possible Reduction of Cardiac Risk after Supplementation with Epigallocatechin Gallate and Increase of Ketone Bodies in the Blood in Patients with Multiple Sclerosis. A Pilot Study" Nutrients 12, no. 12: 3792. https://doi.org/10.3390/nu12123792

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