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Article

Mumefural Improves Blood Flow in a Rat Model of FeCl3-Induced Arterial Thrombosis

by 1,2 and 1,2,*
1
Herbal Medicine Research Division, Korea Institute of Oriental Medicine, 1672 Yuseong-daero, Yuseong-gu, Daejeon 34054, Korea
2
Convergence Research Center for Diagnosis, Treatment and Care System of Dementia, Korea Institute of Science and Technology, 5 Hwarang-ro 14-gil, Seongbuk-gu, Seoul 02792, Korea
*
Author to whom correspondence should be addressed.
Nutrients 2020, 12(12), 3795; https://doi.org/10.3390/nu12123795
Received: 19 October 2020 / Revised: 7 December 2020 / Accepted: 8 December 2020 / Published: 10 December 2020
(This article belongs to the Section Phytochemicals and Human Health)
Mumefural (MF), a bioactive component of the processed fruit of Prunus mume Sieb. et Zucc, is known to inhibit platelet aggregation induced by agonists in vitro. In this study, we investigated the anti-thrombotic effects of MF using a rat model of FeCl3-induced arterial thrombosis. Sprague–Dawley rats were intraperitoneally injected with MF (0.1, 1, or 10 mg/kg) 30 min before 35% FeCl3 treatment to measure the time to occlusion using a laser Doppler flowmeter and to assess the weight of the blood vessels containing thrombus. MF treatment significantly improved blood flow by inhibiting occlusion and thrombus formation. MF also prevented collagen fiber damage in injured vessels and inhibited the expression of the platelet activation-related proteins P-selectin and E-selectin. Moreover, MF significantly reduced the increased inflammatory signal of nuclear factor (NF)-κB, toll-like receptor 4 (TLR4), tumor necrosis factor (TNF)-α, and interleukin (IL)-6 in blood vessels. After administration, MF was detected in the plasma samples of rats with a bioavailability of 36.95%. Therefore, we suggest that MF may improve blood flow as a candidate component in dietary supplements for improving blood flow and preventing blood circulation disorders. View Full-Text
Keywords: mumefural; FeCl3-induced arterial thrombosis; platelet activation mumefural; FeCl3-induced arterial thrombosis; platelet activation
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MDPI and ACS Style

Bang, J.; Jeon, W.K. Mumefural Improves Blood Flow in a Rat Model of FeCl3-Induced Arterial Thrombosis. Nutrients 2020, 12, 3795. https://doi.org/10.3390/nu12123795

AMA Style

Bang J, Jeon WK. Mumefural Improves Blood Flow in a Rat Model of FeCl3-Induced Arterial Thrombosis. Nutrients. 2020; 12(12):3795. https://doi.org/10.3390/nu12123795

Chicago/Turabian Style

Bang, Jihye, and Won K. Jeon 2020. "Mumefural Improves Blood Flow in a Rat Model of FeCl3-Induced Arterial Thrombosis" Nutrients 12, no. 12: 3795. https://doi.org/10.3390/nu12123795

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