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Plasma Branched-Chain and Aromatic Amino Acids in Relation to Hypertension

Department of Public Health and Preventive Medicine, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi 755-8505, Japan
Department of Public Health, Faculty of Veterinary Medicine, Okayama University of Science, Imabari, Ehime 794-8555, Japan
Institute for Innovation, Ajinomoto Co. Inc., Kawasaki, Kanagawa 210-8681, Japan
Author to whom correspondence should be addressed.
Nutrients 2020, 12(12), 3791;
Received: 6 November 2020 / Revised: 7 December 2020 / Accepted: 9 December 2020 / Published: 10 December 2020
(This article belongs to the Special Issue Dietary Interventions for Cardiovascular Risk Reduction)
Findings of the available studies regarding the roles of branched-chain amino acids (BCAAs) and aromatic amino acids (AAAs) in hypertension are inconsistent, conflicting and inconclusive. The purpose of this study was to explore and clarify the existence of any relationships of individual BCAAs and AAAs with hypertension with adjustments for potential relevant confounders. A total of 2805 healthy controls and 2736 hypertensive patients were included in the current analysis. The associations between individual amino acids and hypertension were explored by logistic regression analyses adjusted for potential confounding variables. Among the investigated amino acids, only the BCAAs showed consistently significant positive associations with hypertension in the adjusted models (p-trend < 0.05 to 0.001). However, compared with the corresponding lowest quartile of individual BCAAs, the positive association with hypertension remained significant only in the highest quartile (p < 0.01 to 0.001). We confirmed in a relatively large cohort of subjects that BCAAs, not AAAs, demonstrated consistent positive associations with hypertension. The results display the promising potential for the use of BCAAs as relevant and accessible biomarkers, and provide perspectives on interventions directed towards the reduction in plasma BCAA levels in the prevention and management of hypertension. View Full-Text
Keywords: plasma amino acids; branched-chain; aromatic; hypertension plasma amino acids; branched-chain; aromatic; hypertension
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MDPI and ACS Style

Mahbub, M.H.; Yamaguchi, N.; Hase, R.; Takahashi, H.; Ishimaru, Y.; Watanabe, R.; Saito, H.; Shimokawa, J.; Yamamoto, H.; Kikuchi, S.; Tanabe, T. Plasma Branched-Chain and Aromatic Amino Acids in Relation to Hypertension. Nutrients 2020, 12, 3791.

AMA Style

Mahbub MH, Yamaguchi N, Hase R, Takahashi H, Ishimaru Y, Watanabe R, Saito H, Shimokawa J, Yamamoto H, Kikuchi S, Tanabe T. Plasma Branched-Chain and Aromatic Amino Acids in Relation to Hypertension. Nutrients. 2020; 12(12):3791.

Chicago/Turabian Style

Mahbub, M. H., Natsu Yamaguchi, Ryosuke Hase, Hidekazu Takahashi, Yasutaka Ishimaru, Rie Watanabe, Hiroyuki Saito, Junki Shimokawa, Hiroshi Yamamoto, Shinya Kikuchi, and Tsuyoshi Tanabe. 2020. "Plasma Branched-Chain and Aromatic Amino Acids in Relation to Hypertension" Nutrients 12, no. 12: 3791.

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