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Open AccessArticle

Propolis Suppresses UV-Induced Photoaging in Human Skin through Directly Targeting Phosphoinositide 3-Kinase

1
Department of Biotechnology, Yonsei University, Seoul 03722, Korea
2
Department of Food Science and Technology, Chung-Ang University, Anseong 456-756, Korea
3
Korea Food Research Institute, Wanju 55365, Korea
4
Division of Bioengineering, Incheon National University, Incheon 22012, Korea
5
Department of Agricultural Biology, National Institute of Agricultural Science, Rural Development Administration, Wanju 55365, Korea
6
Department of Food Science & Biotechnology, Sejong University, Seoul 05006, Korea
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Nutrients 2020, 12(12), 3790; https://doi.org/10.3390/nu12123790
Received: 21 October 2020 / Revised: 4 December 2020 / Accepted: 8 December 2020 / Published: 10 December 2020
Propolis is a resinous substance generated by bees using materials from various plant sources. It has been known to exhibit diverse bioactivities including anti-oxidative, anti-microbial, anti-inflammatory, and anti-cancer effects. However, the direct molecular target of propolis and its therapeutic potential against skin aging in humans is not fully understood. Herein, we investigated the effect of propolis on ultraviolet (UV)-mediated skin aging and its underlying molecular mechanism. Propolis suppressed UV-induced matrix metalloproteinase (MMP)-1 production in human dermal fibroblasts. More importantly, propolis treatment reduced UV-induced MMP-1 expression and blocked collagen degradation in human skin tissues, suggesting that the anti-skin-aging activity of propolis can be recapitulated in clinically relevant conditions. While propolis treatment did not display any noticeable effects against extracellular signal-regulated kinase (ERK), p38, and c-jun N-terminal kinase (JNK) pathways, propolis exerted significant inhibitory activity specifically against phosphorylations of phosphoinositide-dependent protein kinase-1 (PDK1) and protein kinase B (Akt). Kinase assay results demonstrated that propolis can directly suppress phosphoinositide 3-kinase (PI3K) activity, with preferential selectivity towards PI3K with p110α and p110δ catalytic subunits over other kinases. The content of active compounds was quantified, and among the compounds identified from the propolis extract, caffeic acid phenethyl ester, quercetin, and apigenin were shown to attenuate PI3K activity. These results demonstrate that propolis shows anti-skin-aging effects through direct inhibition of PI3K activity. View Full-Text
Keywords: propolis; skin; matrix metalloproteinase-1; UV; phosphoinositide 3-kinase propolis; skin; matrix metalloproteinase-1; UV; phosphoinositide 3-kinase
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MDPI and ACS Style

Kim, D.H.; Auh, J.-H.; Oh, J.; Hong, S.; Choi, S.; Shin, E.J.; Woo, S.O.; Lim, T.-G.; Byun, S. Propolis Suppresses UV-Induced Photoaging in Human Skin through Directly Targeting Phosphoinositide 3-Kinase. Nutrients 2020, 12, 3790. https://doi.org/10.3390/nu12123790

AMA Style

Kim DH, Auh J-H, Oh J, Hong S, Choi S, Shin EJ, Woo SO, Lim T-G, Byun S. Propolis Suppresses UV-Induced Photoaging in Human Skin through Directly Targeting Phosphoinositide 3-Kinase. Nutrients. 2020; 12(12):3790. https://doi.org/10.3390/nu12123790

Chicago/Turabian Style

Kim, Da H.; Auh, Joong-Hyuck; Oh, Jeongyeon; Hong, Seungpyo; Choi, Sungbin; Shin, Eun J.; Woo, Soon O.; Lim, Tae-Gyu; Byun, Sanguine. 2020. "Propolis Suppresses UV-Induced Photoaging in Human Skin through Directly Targeting Phosphoinositide 3-Kinase" Nutrients 12, no. 12: 3790. https://doi.org/10.3390/nu12123790

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