Effects of Chlorogenic Acids on Menopausal Symptoms in Healthy Women: A Randomized, Placebo-Controlled, Double-Blind, Parallel-Group Trial
Abstract
:1. Introduction
2. Materials and Methods
2.1. Study Design
2.2. Subjects
2.3. Test Tablets
2.4. Assessment of Hot Flushes and Sweats
2.5. Assessment of Menopausal Symptoms, HRQOL, and Anxiety
2.6. Statistical Analysis
3. Results
3.1. Number of Hot Flushes and Sweats
3.2. Severities of Hot Flushes and Sweats (VAS Assessment)
3.3. Menopausal Symptoms
3.4. HRQOL and Anxiety
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Placebo | CGA | Test Statistic | |
---|---|---|---|
n = 38 | n = 39 | ||
Age (years) | 48.2, 51.0, 55.0 (51.4 ± 4.3) | 48.0, 51.0, 54.5 (51.3 ± 4.6) | |
Height (cm) | 155.0, 159.5, 162.0 (158.4 ± 5.0) | 155.5, 158.0, 162.0 (158.5 ± 4.7) | |
Body weight (kg) | 49.2, 54.5, 60.0 (55.0 ± 7.2) | 51.0, 55.0, 59.0 (54.9 ± 6.9) | |
BMI (kg/m2) | 19.6, 21.7, 23.7 (22.0 ± 3.1) | 19.9, 21.3, 23.2 (21.9 ± 2.8) | |
mKMI total score | 17.2, 22.0, 27.8 (23.1 ± 8.0) | 16.0, 22.0, 27.5 (22.5 ± 8.0) | |
Menopause Status | |||
Premenopausal | 16% (6) | 15% (6) | |
Perimenopausal | 32% (12) | 36% (14) | |
Postmenopausal | 53% (20) | 46% (18) | |
Missing | 0% (0) | 3% (1) |
Baseline | Change from Baseline at Week 4 | Difference of Change | |||||
---|---|---|---|---|---|---|---|
Placebo | CGA | Placebo | p-Value | CGA | p-Value | p-Value | |
n = 38 | n = 39 | n = 38 | Within Groups | n = 39 | Within Groups | Between Groups | |
SF-8 | |||||||
PCS-8 score | 43.4 ± 1.0 | 45.7 ± 1.1 | 2.6 ± 1.1 | 0.018 * | 2.4 ± 1.1 | 0.025 * | 0.712 |
MCS-8 score | 44.6 ± 1.3 | 44.7 ± 1.3 | 4.7 ± 1.1 | <0.001 * | 3.5 ± 1.2 | 0.004 * | 0.308 |
STAI | |||||||
State anxiety | 45.7 ± 1.7 | 46.5 ± 1.6 | −4.8 ± 1.5 | 0.003 * | −4.5 ± 1.3 | 0.002 * | 0.560 |
Trait anxiety | 50.2 ± 1.9 | 48.4 ± 1.7 | −4.6 ± 1.1 | <0.001 * | −4.0 ± 1.1 | 0.004 * | 0.465 |
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Enokuchi, Y.; Suzuki, A.; Yamaguchi, T.; Ochiai, R.; Terauchi, M.; Kataoka, K. Effects of Chlorogenic Acids on Menopausal Symptoms in Healthy Women: A Randomized, Placebo-Controlled, Double-Blind, Parallel-Group Trial. Nutrients 2020, 12, 3757. https://doi.org/10.3390/nu12123757
Enokuchi Y, Suzuki A, Yamaguchi T, Ochiai R, Terauchi M, Kataoka K. Effects of Chlorogenic Acids on Menopausal Symptoms in Healthy Women: A Randomized, Placebo-Controlled, Double-Blind, Parallel-Group Trial. Nutrients. 2020; 12(12):3757. https://doi.org/10.3390/nu12123757
Chicago/Turabian StyleEnokuchi, Yuka, Atsushi Suzuki, Tohru Yamaguchi, Ryuji Ochiai, Masakazu Terauchi, and Kiyoshi Kataoka. 2020. "Effects of Chlorogenic Acids on Menopausal Symptoms in Healthy Women: A Randomized, Placebo-Controlled, Double-Blind, Parallel-Group Trial" Nutrients 12, no. 12: 3757. https://doi.org/10.3390/nu12123757