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Open AccessArticle

Depressive Symptoms in Middle-Aged and Elderly Women Are Associated with a Low Intake of Vitamin B6: A Cross-Sectional Study

1
Department of Women’s Health, Tokyo Medical and Dental University, Tokyo 113-8510, Japan
2
Department of Obstetrics and Gynecology, Tokyo Medical and Dental University, Tokyo 113-8510, Japan
*
Author to whom correspondence should be addressed.
Nutrients 2020, 12(11), 3437; https://doi.org/10.3390/nu12113437
Received: 6 October 2020 / Revised: 29 October 2020 / Accepted: 4 November 2020 / Published: 9 November 2020
(This article belongs to the Special Issue Nutrition Challenges for Middle-Aged and Older Women)
This study investigated the nutritional factors that are associated with anxiety and depressive symptoms in Japanese middle-aged and elderly women. We conducted a cross-sectional study with 289 study participants aged ≥40 years (mean age = 52.0 ± 6.9 years). Their dietary habits, menopausal status and symptoms, and varied background factors, such as body composition, lifestyle factors, and cardiovascular parameters, were assessed. Their anxiety and depressive symptoms were evaluated using the Hospital Anxiety and Depression Scale (HADS), where scores of 0–7 points, 8–10 points, and 11–21 points on either the anxiety or depression subscales were categorized as mild, moderate, and severe, respectively. The dietary consumption of nutrients was assessed using a brief self-administered diet history questionnaire. The relationships between the moderate-to-severe anxiety/depressive symptoms and the dietary intake of 43 major nutrients were investigated using multivariate logistic regression analyses. After adjusting for age, menopausal status, and the background factors that were significantly related to depressive symptoms, moderate and severe depression was significantly inversely associated with only vitamin B6 (adjusted odds ratio per 10 μg/MJ in vitamin B6 intake = 0.89, 95% confidence interval = 0.80–0.99). A higher intake of vitamin B6 could help relieve depressive symptoms for this population. View Full-Text
Keywords: depression; anxiety; menopause; mental disorder; pyridoxal 5′-phosphate depression; anxiety; menopause; mental disorder; pyridoxal 5′-phosphate
MDPI and ACS Style

Odai, T.; Terauchi, M.; Suzuki, R.; Kato, K.; Hirose, A.; Miyasaka, N. Depressive Symptoms in Middle-Aged and Elderly Women Are Associated with a Low Intake of Vitamin B6: A Cross-Sectional Study. Nutrients 2020, 12, 3437.

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