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Open AccessArticle

Dietary Intervention Modulates the Expression of Splicing Machinery in Cardiovascular Patients at High Risk of Type 2 Diabetes Development: From the CORDIOPREV Study

1
Maimonides Institute for Biomedical Research of Cordoba (IMIBIC), 14004 Córdoba, Spain
2
Department of Cell Biology, University of Córdoba, 14004 Córdoba, Spain
3
Reina Sofia University Hospital, 14004 Córdoba, Spain
4
CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), 14004 Córdoba, Spain
5
Lipid and Atherosclerosis Unit, Department of Medicine, Reina Sofia University Hospital, University of Córdoba, 14004 Córdoba, Spain
*
Authors to whom correspondence should be addressed.
Nutrients 2020, 12(11), 3528; https://doi.org/10.3390/nu12113528
Received: 13 October 2020 / Revised: 3 November 2020 / Accepted: 12 November 2020 / Published: 17 November 2020
(This article belongs to the Special Issue Gene–Diet Interactions and Human Diseases)
Type-2 diabetes mellitus (T2DM) has become a major health problem worldwide. T2DM risk can be reduced with healthy dietary interventions, but the precise molecular underpinnings behind this association are still incompletely understood. We recently discovered that the expression profile of the splicing machinery is associated with the risk of T2DM development. Thus, the aim of this work was to evaluate the influence of 3-year dietary intervention in the expression pattern of the splicing machinery components in peripheral blood mononuclear cells (PBMCs) from patients within the CORDIOPREV study. Expression of splicing machinery components was determined in PBMCs, at baseline and after 3 years of follow-up, from all patients who developed T2DM (Incident-T2DM, n = 107) and 108 randomly selected non-T2DM subjects, who were randomly enrolled in two healthy dietary patterns (Mediterranean or low-fat diets). Dietary intervention modulated the expression of key splicing machinery components (i.e., up-regulation of SPFQ/RMB45/RNU6, etc., down-regulation of RNU2/SRSF6) after three years, independently of the type of healthy diet. Some of these changes (SPFQ/RMB45/SRSF6) were associated with key clinical features and were differentially induced in Incident-T2DM patients and non-T2DM subjects. This study reveals that splicing machinery can be modulated by long-term dietary intervention, and could become a valuable tool to screen the progression of T2DM. View Full-Text
Keywords: Low-Fat diet; Mediterranean diet; peripheral blood mononuclear cells (PBMCs); splicing machinery; Type-2 diabetes mellitus Low-Fat diet; Mediterranean diet; peripheral blood mononuclear cells (PBMCs); splicing machinery; Type-2 diabetes mellitus
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MDPI and ACS Style

del Río-Moreno, M.; Luque, R.M.; Rangel-Zúñiga, O.A.; Alors-Pérez, E.; Alcalá-Diaz, J.F.; Roncero-Ramos, I.; Camargo, A.; Gahete, M.D.; López-Miranda, J.; Castaño, J.P. Dietary Intervention Modulates the Expression of Splicing Machinery in Cardiovascular Patients at High Risk of Type 2 Diabetes Development: From the CORDIOPREV Study. Nutrients 2020, 12, 3528. https://doi.org/10.3390/nu12113528

AMA Style

del Río-Moreno M, Luque RM, Rangel-Zúñiga OA, Alors-Pérez E, Alcalá-Diaz JF, Roncero-Ramos I, Camargo A, Gahete MD, López-Miranda J, Castaño JP. Dietary Intervention Modulates the Expression of Splicing Machinery in Cardiovascular Patients at High Risk of Type 2 Diabetes Development: From the CORDIOPREV Study. Nutrients. 2020; 12(11):3528. https://doi.org/10.3390/nu12113528

Chicago/Turabian Style

del Río-Moreno, Mercedes; Luque, Raúl M.; Rangel-Zúñiga, Oriol A.; Alors-Pérez, Emilia; Alcalá-Diaz, Juan F.; Roncero-Ramos, Irene; Camargo, Antonio; Gahete, Manuel D.; López-Miranda, José; Castaño, Justo P. 2020. "Dietary Intervention Modulates the Expression of Splicing Machinery in Cardiovascular Patients at High Risk of Type 2 Diabetes Development: From the CORDIOPREV Study" Nutrients 12, no. 11: 3528. https://doi.org/10.3390/nu12113528

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