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Effects of a Fermented Dairy Drink Containing Lacticaseibacillus paracasei subsp. paracasei CNCM I-1518 (Lactobacillus casei CNCM I-1518) and the Standard Yogurt Cultures on the Incidence, Duration, and Severity of Common Infectious Diseases: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

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Intertek Health Sciences, Inc., Suite 201, 2233 Argentia Road, Mississauga, ON L5N 2X7, Canada
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Danone Nutricia Research, RD 128, 91767 Palaiseau CEDEX, France
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Author to whom correspondence should be addressed.
Nutrients 2020, 12(11), 3443; https://doi.org/10.3390/nu12113443
Received: 6 October 2020 / Revised: 3 November 2020 / Accepted: 3 November 2020 / Published: 10 November 2020
(This article belongs to the Section Prebiotics and Probiotics)
There is considerable interest in the role of probiotics in immune function. The objective of this systematic review and meta-analysis was to assess the effects of the consumption of a fermented dairy drink containing Lacticaseibacillus paracasei subsp. paracasei CNCM I-1518 (the previous taxonomic nomenclature was Lactobacillus casei CNCM I-1518, prior to the nomenclature change in April 2020) and the standard yogurt cultures (hereinafter referred to collectively as “FDD”) on common infectious diseases (CIDs) in generally healthy children and adults. Nine literature databases were searched, and nine randomized controlled trials from eight publications were eligible for inclusion. Combined effect sizes were determined for three metrics of CID incidence, two metrics of CID duration, and one metric of CID severity. Compared to the control, the consumption of the FDD resulted in (1) a significant reduction in the odds of experiencing ≥1 CID (odds ratio (OR) (with a 95% confidence interval (CI)): 0.81 (0.66, 0.98); p = 0.029); (2) a significant reduction in mean CIDs per subject (−0.09 (−0.15, −0.04); p = 0.001); and (3) a trend towards reduced risk in cumulative CIDs (relative risk (RR): 0.91 (0.82, 1.01); p = 0.082). The consumption of the FDD had no significant effect on CID duration or severity. Based on the studies conducted thus far, these results suggest that the FDD may reduce CID incidence in the general population. View Full-Text
Keywords: Lacticaseibacillus paracasei subsp. paracasei CNCM I-1518; Lactobacillus casei CNCM I-1518; Lactobacillus casei DN-114 001; fermented dairy; fermented milk; probiotic; common infectious disease; respiratory infection; gastrointestinal infection; immune function Lacticaseibacillus paracasei subsp. paracasei CNCM I-1518; Lactobacillus casei CNCM I-1518; Lactobacillus casei DN-114 001; fermented dairy; fermented milk; probiotic; common infectious disease; respiratory infection; gastrointestinal infection; immune function
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MDPI and ACS Style

Poon, T.; Juana, J.; Noori, D.; Jeansen, S.; Pierucci-Lagha, A.; Musa-Veloso, K. Effects of a Fermented Dairy Drink Containing Lacticaseibacillus paracasei subsp. paracasei CNCM I-1518 (Lactobacillus casei CNCM I-1518) and the Standard Yogurt Cultures on the Incidence, Duration, and Severity of Common Infectious Diseases: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Nutrients 2020, 12, 3443. https://doi.org/10.3390/nu12113443

AMA Style

Poon T, Juana J, Noori D, Jeansen S, Pierucci-Lagha A, Musa-Veloso K. Effects of a Fermented Dairy Drink Containing Lacticaseibacillus paracasei subsp. paracasei CNCM I-1518 (Lactobacillus casei CNCM I-1518) and the Standard Yogurt Cultures on the Incidence, Duration, and Severity of Common Infectious Diseases: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Nutrients. 2020; 12(11):3443. https://doi.org/10.3390/nu12113443

Chicago/Turabian Style

Poon, Theresa, Justine Juana, Daniel Noori, Stephanie Jeansen, Amira Pierucci-Lagha, and Kathy Musa-Veloso. 2020. "Effects of a Fermented Dairy Drink Containing Lacticaseibacillus paracasei subsp. paracasei CNCM I-1518 (Lactobacillus casei CNCM I-1518) and the Standard Yogurt Cultures on the Incidence, Duration, and Severity of Common Infectious Diseases: A Systematic Review and Meta-Analysis of Randomized Controlled Trials" Nutrients 12, no. 11: 3443. https://doi.org/10.3390/nu12113443

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