The Impact of Food Histamine Intake on Asthma Activity: A Pilot Study
Department of Nutritional Sciences and Dietetics, International Hellenic University, 57400 Thessaloniki, Greece
Department of Allergy and Clinical Immunology, 424 General Military Training Hospital, 57400 Thessaloniki, Greece
Allergy Department, 2nd Pediatric Clinic, University of Athens, 11528 Athens, Greece
Department of Nutrition and Dietetics, Harokopio University of Athens, 70 El. Venizelou Avenue, 17671 Kallithea, Greece
Author to whom correspondence should be addressed.
Nutrients 2020, 12(11), 3402; https://doi.org/10.3390/nu12113402
Received: 22 September 2020 / Revised: 21 October 2020 / Accepted: 31 October 2020 / Published: 5 November 2020
(This article belongs to the Special Issue Dietary Interventions for Chronic Pain and Inflammatory Diseases)
Asthma is a complex chronic inflammatory disorder. Diet’s impact on asthma symptoms is controversial. The objective of this pilot crossover, randomized, two-period study was to examine the effect of dietary histamine intake on asthma symptoms in twenty-one children with mild intermittent asthma. Children were randomly assigned to either a high- or low-histamine diet, based on the Mediterranean pattern, for 4 weeks. After a 2-week washout period, patients crossed to the alternative diet for 4 additional weeks. Asthma symptoms were assessed at baseline and after the completion of each diet period by a clinician. Daily symptoms and peak flow were recorded throughout the intervention. Adherence to the dietary intervention was assessed via analysis of four random 24-h recalls, for each intervention period. Eighteen children completed the study. Significantly higher mean air flow obstruction was recorded and a trend for prolonged and more severe symptoms was observed during the high-histamine period. Diet may have an active and direct impact on asthma symptoms. Food choice is affected and/or may affect symptoms in children with mild asthma. Diet intervention is promising yet challenging, for asthma control.