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Article

Dietary Short-Term Fiber Interventions in Arthritis Patients Increase Systemic SCFA Levels and Regulate Inflammation

1
Department of Internal Medicine 3-Rheumatology and Immunology, Friedrich-Alexander University (FAU) Erlangen-Nürnberg and Universitätsklinikum Erlangen, 91054 Erlangen, Germany
2
Deutsches Zentrum für Immuntherapie (DZI), 91054 Erlangen, Germany
3
Department of Biology, Division of Biochemistry, Friedrich-Alexander University (FAU), 91058 Erlangen, Germany
4
Helmholtz Centre for Infection Research, 38124 Braunschweig, Germany
5
Melio.Care GmbH, 91080 Marloffstein, Germany
*
Author to whom correspondence should be addressed.
Nutrients 2020, 12(10), 3207; https://doi.org/10.3390/nu12103207
Received: 23 September 2020 / Revised: 13 October 2020 / Accepted: 16 October 2020 / Published: 20 October 2020
(This article belongs to the Special Issue Dietary Interventions for Chronic Pain and Inflammatory Diseases)
Chronic inflammatory diseases are often initiated and guided by the release of proinflammatory mediators. Rheumatoid arthritis (RA) is caused by an imbalance between the pro- and anti-inflammatory mediators in the joints, thereby favoring chronic inflammation and joint damage. Here, we investigate if short-term high-fiber dietary intervention shifts this towards anti-inflammatory mediators. Healthy controls (n = 10) and RA patients (n = 29) under routine care received daily high-fiber bars for 15 or 30 days, respectively. Stool and sera were analyzed for pro- and anti-inflammatory mediators. A high-fiber dietary intervention resulted in increased anti-inflammatory short-chain fatty acids (SCFA), decreased proarthritic cytokine concentrations, along with a durable shift in the Firmicutes-to-Bacteroidetes ratio. Together, these results further strengthen high-fiber dietary interventions as a practical approach complementing existing pharmacological therapies. View Full-Text
Keywords: high-fiber diet (HFD); microbial metabolites; short chain fatty acids (SCFA) high-fiber diet (HFD); microbial metabolites; short chain fatty acids (SCFA)
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MDPI and ACS Style

Dürholz, K.; Hofmann, J.; Iljazovic, A.; Häger, J.; Lucas, S.; Sarter, K.; Strowig, T.; Bang, H.; Rech, J.; Schett, G.; Zaiss, M.M. Dietary Short-Term Fiber Interventions in Arthritis Patients Increase Systemic SCFA Levels and Regulate Inflammation. Nutrients 2020, 12, 3207. https://doi.org/10.3390/nu12103207

AMA Style

Dürholz K, Hofmann J, Iljazovic A, Häger J, Lucas S, Sarter K, Strowig T, Bang H, Rech J, Schett G, Zaiss MM. Dietary Short-Term Fiber Interventions in Arthritis Patients Increase Systemic SCFA Levels and Regulate Inflammation. Nutrients. 2020; 12(10):3207. https://doi.org/10.3390/nu12103207

Chicago/Turabian Style

Dürholz, Kerstin, Jörg Hofmann, Aida Iljazovic, Julian Häger, Sébastien Lucas, Kerstin Sarter, Till Strowig, Holger Bang, Jürgen Rech, Georg Schett, and Mario M. Zaiss. 2020. "Dietary Short-Term Fiber Interventions in Arthritis Patients Increase Systemic SCFA Levels and Regulate Inflammation" Nutrients 12, no. 10: 3207. https://doi.org/10.3390/nu12103207

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