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Article

The Impact of Food Histamine Intake on Asthma Activity: A Pilot Study

1
Department of Nutritional Sciences and Dietetics, International Hellenic University, 57400 Thessaloniki, Greece
2
Department of Allergy and Clinical Immunology, 424 General Military Training Hospital, 57400 Thessaloniki, Greece
3
Allergy Department, 2nd Pediatric Clinic, University of Athens, 11528 Athens, Greece
4
Department of Nutrition and Dietetics, Harokopio University of Athens, 70 El. Venizelou Avenue, 17671 Kallithea, Greece
*
Author to whom correspondence should be addressed.
Nutrients 2020, 12(11), 3402; https://doi.org/10.3390/nu12113402
Received: 22 September 2020 / Revised: 21 October 2020 / Accepted: 31 October 2020 / Published: 5 November 2020
(This article belongs to the Special Issue Dietary Interventions for Chronic Pain and Inflammatory Diseases)
Asthma is a complex chronic inflammatory disorder. Diet’s impact on asthma symptoms is controversial. The objective of this pilot crossover, randomized, two-period study was to examine the effect of dietary histamine intake on asthma symptoms in twenty-one children with mild intermittent asthma. Children were randomly assigned to either a high- or low-histamine diet, based on the Mediterranean pattern, for 4 weeks. After a 2-week washout period, patients crossed to the alternative diet for 4 additional weeks. Asthma symptoms were assessed at baseline and after the completion of each diet period by a clinician. Daily symptoms and peak flow were recorded throughout the intervention. Adherence to the dietary intervention was assessed via analysis of four random 24-h recalls, for each intervention period. Eighteen children completed the study. Significantly higher mean air flow obstruction was recorded and a trend for prolonged and more severe symptoms was observed during the high-histamine period. Diet may have an active and direct impact on asthma symptoms. Food choice is affected and/or may affect symptoms in children with mild asthma. Diet intervention is promising yet challenging, for asthma control. View Full-Text
Keywords: asthma; nutritional intervention; food histamine; Mediterranean diet; Western diet; antioxidants; anti-inflammatory diet asthma; nutritional intervention; food histamine; Mediterranean diet; Western diet; antioxidants; anti-inflammatory diet
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MDPI and ACS Style

Vassilopoulou, E.; Konstantinou, G.N.; Dimitriou, A.; Manios, Y.; Koumbi, L.; Papadopoulos, N.G. The Impact of Food Histamine Intake on Asthma Activity: A Pilot Study. Nutrients 2020, 12, 3402. https://doi.org/10.3390/nu12113402

AMA Style

Vassilopoulou E, Konstantinou GN, Dimitriou A, Manios Y, Koumbi L, Papadopoulos NG. The Impact of Food Histamine Intake on Asthma Activity: A Pilot Study. Nutrients. 2020; 12(11):3402. https://doi.org/10.3390/nu12113402

Chicago/Turabian Style

Vassilopoulou, Emilia, George N. Konstantinou, Anastasia Dimitriou, Yannis Manios, Lemonica Koumbi, and Nikolaos G. Papadopoulos. 2020. "The Impact of Food Histamine Intake on Asthma Activity: A Pilot Study" Nutrients 12, no. 11: 3402. https://doi.org/10.3390/nu12113402

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