Next Article in Journal
Effects of Interval Jump Rope Exercise Combined with Dark Chocolate Supplementation on Inflammatory Adipokine, Cytokine Concentrations, and Body Composition in Obese Adolescent Boys
Next Article in Special Issue
Impacts of Acute Sucralose and Glucose on Brain Activity during Food Decisions in Humans
Previous Article in Journal
Plant Fortification of the Diet for Anti-Ageing Effects: A Review
Previous Article in Special Issue
Underlying Susceptibility to Eating Disorders and Drug Abuse: Genetic and Pharmacological Aspects of Dopamine D4 Receptors
 
 
Review

How Does Our Brain Process Sugars and Non-Nutritive Sweeteners Differently: A Systematic Review on Functional Magnetic Resonance Imaging Studies

1
Oral and Maxillofacial Radiology, Applied Oral Sciences and Community Dental Care, Faculty of Dentistry, The University of Hong Kong, Hong Kong, China
2
Oral and Maxillofacial Surgery, Faculty of Dentistry, The University of Hong Kong, Hong Kong, China
*
Author to whom correspondence should be addressed.
Nutrients 2020, 12(10), 3010; https://doi.org/10.3390/nu12103010
Received: 28 August 2020 / Revised: 28 September 2020 / Accepted: 28 September 2020 / Published: 30 September 2020
(This article belongs to the Special Issue Brain and Food Motivation, Choice, and Eating Behavior)
This systematic review aimed to reveal the differential brain processing of sugars and sweeteners in humans. Functional magnetic resonance imaging studies published up to 2019 were retrieved from two databases and were included into the review if they evaluated the effects of both sugars and sweeteners on the subjects’ brain responses, during tasting and right after ingestion. Twenty studies fulfilled the inclusion criteria. The number of participants per study ranged from 5 to 42, with a total number of study participants at 396. Seven studies recruited both males and females, 7 were all-female and 6 were all-male. There was no consistent pattern showing that sugar or sweeteners elicited larger brain responses. Commonly involved brain regions were insula/operculum, cingulate and striatum, brainstem, hypothalamus and the ventral tegmental area. Future studies, therefore, should recruit a larger sample size, adopt a standardized fasting duration (preferably 12 h overnight, which is the most common practice and brain responses are larger in the state of hunger), and reported results with familywise-error rate (FWE)-corrected statistics. Every study should report the differential brain activation between sugar and non-nutritive sweetener conditions regardless of the complexity of their experiment design. These measures would enable a meta-analysis, pooling data across studies in a meaningful manner. View Full-Text
Keywords: neuroimaging; eating; obesity; sugar; sweetener neuroimaging; eating; obesity; sugar; sweetener
Show Figures

Figure 1

MDPI and ACS Style

Yeung, A.W.K.; Wong, N.S.M. How Does Our Brain Process Sugars and Non-Nutritive Sweeteners Differently: A Systematic Review on Functional Magnetic Resonance Imaging Studies. Nutrients 2020, 12, 3010. https://doi.org/10.3390/nu12103010

AMA Style

Yeung AWK, Wong NSM. How Does Our Brain Process Sugars and Non-Nutritive Sweeteners Differently: A Systematic Review on Functional Magnetic Resonance Imaging Studies. Nutrients. 2020; 12(10):3010. https://doi.org/10.3390/nu12103010

Chicago/Turabian Style

Yeung, Andy Wai Kan, and Natalie Sui Miu Wong. 2020. "How Does Our Brain Process Sugars and Non-Nutritive Sweeteners Differently: A Systematic Review on Functional Magnetic Resonance Imaging Studies" Nutrients 12, no. 10: 3010. https://doi.org/10.3390/nu12103010

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop