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Article

Is There a Link between Zinc Intake and Status with Plasma Fatty Acid Profile and Desaturase Activities in Dyslipidemic Subjects?

1
Centre of Research Excellence in Nutrition and Metabolism, Institute for Medical Research, University of Belgrade, 11000 Belgrade, Serbia
2
Institute for Public Health Pozarevac, Jovana Serbanovica 14, 12000 Pozarevac, Serbia
*
Author to whom correspondence should be addressed.
Nutrients 2020, 12(1), 93; https://doi.org/10.3390/nu12010093
Received: 14 November 2019 / Revised: 11 December 2019 / Accepted: 24 December 2019 / Published: 28 December 2019
The prevalence of obesity and dyslipidemia has increased worldwide. The role of trace elements in the pathogenesis of these conditions is not well understood. This study examines the relationship between dietary zinc (Zn) intake and plasma concentrations of Zn, copper (Cu) and iron (Fe) with lipid profile indicators, fatty acid composition in plasma phospholipids and desaturase enzyme activities in a dyslipidemic population. The role of the newly proposed biomarker of Zn status, the linoleic:dihomo-gama-linolenic acid (LA:DGLA) ratio, in predicting Zn status of dyslipidemic subjects has been explored. The study included 27 dyslipidemic adults, 39–72 years old. Trace elements were determined using atomic absorption spectrometry and fatty acid composition by a liquid gas chromatography. Desaturase activities were calculated from product-precursor fatty acid ratios. Dietary data were obtained using 24 h recall questionnaires. Insufficient dietary intake of Zn, low plasma Zn concentrations and an altered Cu:Zn ratio is related to modified fatty acid profile in subjects with dyslipidemia. Plasma Zn status was associated with obesity. There was no correlation between dietary Zn intake and plasma Zn status. The LA:DGLA ratio was inversely linked to dietary Zn intake. Cu, in addition to Zn, may directly or indirectly, affect the activity of desaturase enzymes. View Full-Text
Keywords: Zn deficiency; Zn status; fatty acids; dyslipidemia; desaturases; dietary Zn intake Zn deficiency; Zn status; fatty acids; dyslipidemia; desaturases; dietary Zn intake
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MDPI and ACS Style

Knez, M.; Pantovic, A.; Zekovic, M.; Pavlovic, Z.; Glibetic, M.; Zec, M. Is There a Link between Zinc Intake and Status with Plasma Fatty Acid Profile and Desaturase Activities in Dyslipidemic Subjects? Nutrients 2020, 12, 93. https://doi.org/10.3390/nu12010093

AMA Style

Knez M, Pantovic A, Zekovic M, Pavlovic Z, Glibetic M, Zec M. Is There a Link between Zinc Intake and Status with Plasma Fatty Acid Profile and Desaturase Activities in Dyslipidemic Subjects? Nutrients. 2020; 12(1):93. https://doi.org/10.3390/nu12010093

Chicago/Turabian Style

Knez, Marija; Pantovic, Ana; Zekovic, Milica; Pavlovic, Zoran; Glibetic, Maria; Zec, Manja. 2020. "Is There a Link between Zinc Intake and Status with Plasma Fatty Acid Profile and Desaturase Activities in Dyslipidemic Subjects?" Nutrients 12, no. 1: 93. https://doi.org/10.3390/nu12010093

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