Next Article in Journal
Caffeine Consumption in Switzerland: Results from the First National Nutrition Survey MenuCH
Previous Article in Journal
Repeatability of Taste Recognition Threshold Measurements with QUEST and Quick Yes–No
Previous Article in Special Issue
The Effect of a Low Glycemic Index Pulse-Based Diet on Insulin Sensitivity, Insulin Resistance, Bone Resorption and Cardiovascular Risk Factors during Bed Rest
Open AccessArticle

Effects of Sucralose Ingestion versus Sucralose Taste on Metabolic Responses to an Oral Glucose Tolerance Test in Participants with Normal Weight and Obesity: A Randomized Crossover Trial

1
Department of Food Science and Human Nutrition, University of Illinois at Urbana-Champaign, Urbana, IL 61822, USA
2
Division of Nutritional Sciences, University of Illinois at Urbana-Champaign, Urbana, IL 61822, USA
3
National Institutes of Health, Bethesda, MD 20892, USA
*
Author to whom correspondence should be addressed.
Nutrients 2020, 12(1), 29; https://doi.org/10.3390/nu12010029
Received: 19 November 2019 / Revised: 16 December 2019 / Accepted: 18 December 2019 / Published: 20 December 2019
(This article belongs to the Special Issue The Role of Diet on Insulin Sensitivity)
Here, we tested the hypothesis that sucralose differentially affects metabolic responses to labeled oral glucose tolerance tests (OGTTs) in participants with normal weight and obesity. Participants (10 with normal weight and 11 with obesity) without diabetes underwent three dual-tracer OGTTs preceded, in a randomized order, by consuming sucralose or water, or by tasting and expectorating sucralose (e.g., sham-fed; sweetness control). Indices of β-cell function and insulin sensitivity (SI) were estimated using oral minimal models of glucose, insulin, and C-peptide kinetics. Compared with water, sucralose ingested (but not sham-fed) resulted in a 30 ± 10% increased glucose area under the curve in both weight groups. In contrast, the insulin response to sucralose ingestion differed depending on the presence of obesity: decreased within 20–40 min of the OGTT in normal-weight participants but increased within 90–120 min in participants with obesity. Sham-fed sucralose similarly decreased insulin concentrations within 60 min of the OGTT in both weight groups. Sucralose ingested (but not sham-fed) increased SI in normal-weight participants by 52 ± 20% but did not affect SI in participants with obesity. Sucralose did not affect glucose rates of appearance or β-cell function in either weight group. Our data underscore a physiological role for taste perception in postprandial glucose responses, suggesting sweeteners should be consumed in moderation. View Full-Text
Keywords: low-calorie sweeteners; artificial sweeteners; non-nutritive sweeteners; sucralose; glucose metabolism; oral glucose tolerance test; insulin low-calorie sweeteners; artificial sweeteners; non-nutritive sweeteners; sucralose; glucose metabolism; oral glucose tolerance test; insulin
Show Figures

Figure 1

MDPI and ACS Style

Nichol, A.D.; Salame, C.; Rother, K.I.; Pepino, M.Y. Effects of Sucralose Ingestion versus Sucralose Taste on Metabolic Responses to an Oral Glucose Tolerance Test in Participants with Normal Weight and Obesity: A Randomized Crossover Trial. Nutrients 2020, 12, 29.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop