Effects of Sucralose Ingestion versus Sucralose Taste on Metabolic Responses to an Oral Glucose Tolerance Test in Participants with Normal Weight and Obesity: A Randomized Crossover Trial

Nichol, Alexander D.; Salame, Clara; Rother, Kristina I.; Pepino, M. Yanina

doi:10.3390/nu12010029

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Effects of Sucralose Ingestion versus Sucralose Taste on Metabolic Responses to an Oral Glucose Tolerance Test in Participants with Normal Weight and Obesity: A Randomized Crossover Trial

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Department of Food Science and Human Nutrition, University of Illinois at Urbana-Champaign, Urbana, IL 61822, USA

Division of Nutritional Sciences, University of Illinois at Urbana-Champaign, Urbana, IL 61822, USA

National Institutes of Health, Bethesda, MD 20892, USA

Author to whom correspondence should be addressed.

Nutrients 2020, 12(1), 29; https://doi.org/10.3390/nu12010029

Received: 19 November 2019 / Revised: 16 December 2019 / Accepted: 18 December 2019 / Published: 20 December 2019

(This article belongs to the Special Issue The Role of Diet on Insulin Sensitivity)

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Abstract

Here, we tested the hypothesis that sucralose differentially affects metabolic responses to labeled oral glucose tolerance tests (OGTTs) in participants with normal weight and obesity. Participants (10 with normal weight and 11 with obesity) without diabetes underwent three dual-tracer OGTTs preceded, in a randomized order, by consuming sucralose or water, or by tasting and expectorating sucralose (e.g., sham-fed; sweetness control). Indices of β-cell function and insulin sensitivity (S_I) were estimated using oral minimal models of glucose, insulin, and C-peptide kinetics. Compared with water, sucralose ingested (but not sham-fed) resulted in a 30 ± 10% increased glucose area under the curve in both weight groups. In contrast, the insulin response to sucralose ingestion differed depending on the presence of obesity: decreased within 20–40 min of the OGTT in normal-weight participants but increased within 90–120 min in participants with obesity. Sham-fed sucralose similarly decreased insulin concentrations within 60 min of the OGTT in both weight groups. Sucralose ingested (but not sham-fed) increased S_I in normal-weight participants by 52 ± 20% but did not affect S_I in participants with obesity. Sucralose did not affect glucose rates of appearance or β-cell function in either weight group. Our data underscore a physiological role for taste perception in postprandial glucose responses, suggesting sweeteners should be consumed in moderation. View Full-Text

Keywords: low-calorie sweeteners; artificial sweeteners; non-nutritive sweeteners; sucralose; glucose metabolism; oral glucose tolerance test; insulin

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Nichol, A.D.; Salame, C.; Rother, K.I.; Pepino, M.Y. Effects of Sucralose Ingestion versus Sucralose Taste on Metabolic Responses to an Oral Glucose Tolerance Test in Participants with Normal Weight and Obesity: A Randomized Crossover Trial. Nutrients 2020, 12, 29. https://doi.org/10.3390/nu12010029

AMA Style

Nichol AD, Salame C, Rother KI, Pepino MY. Effects of Sucralose Ingestion versus Sucralose Taste on Metabolic Responses to an Oral Glucose Tolerance Test in Participants with Normal Weight and Obesity: A Randomized Crossover Trial. Nutrients. 2020; 12(1):29. https://doi.org/10.3390/nu12010029

Chicago/Turabian Style

Nichol, Alexander D., Clara Salame, Kristina I. Rother, and M. Y. Pepino. 2020. "Effects of Sucralose Ingestion versus Sucralose Taste on Metabolic Responses to an Oral Glucose Tolerance Test in Participants with Normal Weight and Obesity: A Randomized Crossover Trial" Nutrients 12, no. 1: 29. https://doi.org/10.3390/nu12010029

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Effects of Sucralose Ingestion versus Sucralose Taste on Metabolic Responses to an Oral Glucose Tolerance Test in Participants with Normal Weight and Obesity: A Randomized Crossover Trial

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