Next Article in Journal
Gut Microbiota Modulation by Dietary Barley Malt Melanoidins
Previous Article in Journal
Lack of Differences in Inflammation and T Cell-Mediated Function between Young and Older Women with Obesity
Previous Article in Special Issue
Efficacy of Isomaltulose Compared to Sucrose in Modulating Endothelial Function in Overweight Adults
Open AccessArticle

Endothelial Dysfunction and Advanced Glycation End Products in Patients with Newly Diagnosed Versus Established Diabetes: From the CORDIOPREV Study

1
Lipids and Atherosclerosis Unit, Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC)/Reina Sofia University Hospital/University of Córdoba, 14004 Córdoba, Spain
2
CIBER Fisiopatología Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, 28029 Madrid, Spain
3
Department of Cell Biology, Physiology and Immunology, University of Cordoba, 14004 Córdoba, Spain
4
First Department of Internal Medicine, Division of Endocrinology-Metabolism, Diabetes Center, AHEPA University Hospital, 546 21 Thessaloniki, Greece
*
Author to whom correspondence should be addressed.
Both authors contributed equally to this work.
Nutrients 2020, 12(1), 238; https://doi.org/10.3390/nu12010238
Received: 16 December 2019 / Revised: 7 January 2020 / Accepted: 14 January 2020 / Published: 16 January 2020
(This article belongs to the Special Issue Nutrition on Endothelial Function)
Endothelial dysfunction and intima-media thickness of common carotid arteries (IMT-CC) are considered subclinical markers of atherosclerotic cardiovascular disease (ASCVD). Advanced glycation end products (AGEs) are increased in type 2 diabetes mellitus (T2DM) patients, compared with non-diabetics, being implicated in micro- and macrovascular complications. Our aim was to compare serum AGEs levels and subclinical atherosclerotic markers between patients with established and newly diagnosed T2DM. Among 540 patients with T2DM and coronary heart disease from the CORDIOPREV study, 350 patients had established T2DM and 190 patients had newly diagnosed T2DM. Serum levels of AGEs (methylglyoxal (MG) and N-carboxymethyl lysine (CML)) and subclinical atherosclerotic markers (brachial flow-mediated vasodilation (FMD) and IMT-CC) were measured. AGEs levels (all p < 0.001) and IMT-CC (p = 0.025) were higher in patients with established vs. newly diagnosed T2DM, whereas FMD did not differ between the two groups. Patients with established T2DM and severe endothelial dysfunction (i.e., FMD < 2%) had higher serum MG levels, IMT-CC, HOMA-IR and fasting insulin levels than those with newly diagnosed T2DM and non-severe endothelial dysfunction (i.e., FMD ≥ 2%) (all p < 0.05). Serum CML levels were greater in patients with established vs. newly diagnosed T2DM, regardless of endothelial dysfunction severity. Serum AGEs levels and IMT-CC were significantly higher in patients with established vs. newly diagnosed T2DM, highlighting the progressively increased risk of ASCVD in the course of T2DM. Establishing therapeutic strategies to reduce AGEs production and delay the onset of cardiovascular complications in newly diagnosed T2DM patients or minimize ASCVD risk in established T2DM patients is needed. View Full-Text
Keywords: CORDIOPREV; type 2 diabetes mellitus; endothelial dysfunction; advanced glycation end products; methylglyoxal; N-carboxymethyl lysine; flow-mediated vasodilation; intima-media thickness of common carotid arteries CORDIOPREV; type 2 diabetes mellitus; endothelial dysfunction; advanced glycation end products; methylglyoxal; N-carboxymethyl lysine; flow-mediated vasodilation; intima-media thickness of common carotid arteries
Show Figures

Graphical abstract

MDPI and ACS Style

de la Cruz-Ares, S.; P. Cardelo, M.; M. Gutiérrez-Mariscal, F.; D. Torres-Peña, J.; García-Rios, A.; Katsiki, N.; M. Malagón, M.; López-Miranda, J.; Pérez-Martínez, P.; M. Yubero-Serrano, E. Endothelial Dysfunction and Advanced Glycation End Products in Patients with Newly Diagnosed Versus Established Diabetes: From the CORDIOPREV Study. Nutrients 2020, 12, 238.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop