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Relationship of Wine Consumption with Alzheimer’s Disease

Deptartment of Medical, Oral and Biotechnological Sciences, University “G. d’Annunzio” Chieti-Pescara, 65100 Chieti, Italy
Department of Pharmacy, Abdul Wali Khan University, Mardan 23200, Pakistan
College of Biosystems Engineering and Food Science, Zhejiang University, Hangzhou 310027, China
Author to whom correspondence should be addressed.
Nutrients 2020, 12(1), 206;
Received: 28 December 2019 / Revised: 7 January 2020 / Accepted: 8 January 2020 / Published: 13 January 2020
(This article belongs to the Special Issue Alcoholic Beverages and Human Health)
Background: Alzheimer’s disease (AD), the most threatening neurodegenerative disease, is characterized by the loss of memory and language function, an unbalanced perception of space, and other cognitive and physical manifestations. The pathology of AD is characterized by neuronal loss and the extensive distribution of senile plaques and neurofibrillary tangles (NFTs). The role of environment and the diet in AD is being actively studied, and nutrition is one of the main factors playing a prominent role in the prevention of neurodegenerative diseases. In this context, the relationship between dementia and wine use/abuse has received increased research interest, with varying and often conflicting results. Scope and Approach: With this review, we aimed to critically summarize the main relevant studies to clarify the relationship between wine drinking and AD, as well as how frequency and/or amount of drinking may influence the effects. Key Findings and Conclusions: Overall, based on the interpretation of various studies, no definitive results highlight if light to moderate alcohol drinking is detrimental to cognition and dementia, or if alcohol intake could reduce risk of developing AD. View Full-Text
Keywords: alcohol consumption; Alzheimer’s disease; light to moderate wine consumption; neurodegeneration alcohol consumption; Alzheimer’s disease; light to moderate wine consumption; neurodegeneration
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Reale, M.; Costantini, E.; Jagarlapoodi, S.; Khan, H.; Belwal, T.; Cichelli, A. Relationship of Wine Consumption with Alzheimer’s Disease. Nutrients 2020, 12, 206.

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