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Attenuation of Weight Gain and Prevention of Associated Pathologies by Inhibiting SSAO

1
School of Life Science, Beijing Institute of Technology, Beijing 100081, China
2
Beijing Key Laboratory for Separation and Analysis in Biomedicine and Pharmaceuticals, Beijing 100081, China
*
Author to whom correspondence should be addressed.
Nutrients 2020, 12(1), 184; https://doi.org/10.3390/nu12010184
Received: 11 December 2019 / Revised: 6 January 2020 / Accepted: 7 January 2020 / Published: 9 January 2020
(This article belongs to the Section Nutrition and Metabolism)
Obesity is a worldwide prevalent metabolic disorder that is associated with diabetes, among many other diseases. Bearing this in mind, prevention and treatment ways need to be improved. Notably, activity of the enzyme semicarbazide-sensitive amine oxidase (SSAO) is found to be elevated in overweight subjects. Moreover, SSAO inhibition has resulted in an increase of histamine activity in adipose tissue and the limitation of body fat. The current review aims to overview the risks of obesity, rationalize the molecular ways of SSAO activity, and outline the strategies of inhibiting upregulated enzyme levels. It describes the differences between SSAO inhibitors and advances the prospective agents. Based on evidence, caffeine is proposed as an effective, safe, and reliable choice to inhibit SSAO activity. Furthermore, the histamine in adipocytes has been associated with SSAO activity. Therefore, it is suggested as one of the key compounds to be studied for obesity management. To conclude, inhibiting SSAO may attenuate weight gain and prevent related diseases. View Full-Text
Keywords: obesity; semicarbazide-sensitive amine oxidase (SSAO); caffeine; histamine; diabetes obesity; semicarbazide-sensitive amine oxidase (SSAO); caffeine; histamine; diabetes
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MDPI and ACS Style

Papukashvili, D.; Rcheulishvili, N.; Deng, Y. Attenuation of Weight Gain and Prevention of Associated Pathologies by Inhibiting SSAO. Nutrients 2020, 12, 184.

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