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Impact of Nutrition on Pulmonary Arterial Hypertension

Department of Pharmacology and Toxicology, School of Medicine, Universidad Complutense de Madrid, 28040 Madrid, Spain
CIBER Enfermedades Respiratorias, Ciberes, 28029 Madrid, Spain
Instituto de Investigación Sanitaria Gregorio Marañón (IISGM), 28007 Madrid, Spain
Department of Pulmonary Medicine, Hospital Clínic-Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Universitat de Barcelona, 08036Barcelona, Spain
Department of Pharmacology, School of Pharmacy, Universidad de Granada, 18071 Granada, Spain
CIBER Enfermedades Cardiovasculares, CiberCV, 28029 Madrid, Spain
Instituto de Investigación Biosanitaria (ibs.Granada), 18012 Granada, Spain
Centro de Investigaciones Biomédicas (CIBM), 18016 Granada, Spain
Author to whom correspondence should be addressed.
Nutrients 2020, 12(1), 169;
Received: 6 November 2019 / Revised: 26 December 2019 / Accepted: 3 January 2020 / Published: 7 January 2020
(This article belongs to the Special Issue Respiratory Disease and Nutrition)
Pulmonary arterial hypertension (PAH) is characterized by sustained vasoconstriction, vascular remodeling, inflammation, and in situ thrombosis. Although there have been important advances in the knowledge of the pathophysiology of PAH, it remains a debilitating, limiting, and rapidly progressive disease. Vitamin D and iron deficiency are worldwide health problems of pandemic proportions. Notably, these nutritional alterations are largely more prevalent in PAH patients than in the general population and there are several pieces of evidence suggesting that they may trigger or aggravate disease progression. There are also several case reports associating scurvy, due to severe vitamin C deficiency, with PAH. Flavonoids such as quercetin, isoflavonoids such as genistein, and other dietary polyphenols including resveratrol slow the progression of the disease in animal models of PAH. Finally, the role of the gut microbiota and its interplay with the diet, host immune system, and energy metabolism is emerging in multiple cardiovascular diseases. The alteration of the gut microbiota has also been reported in animal models of PAH. It is thus possible that in the near future interventions targeting the nutritional status and the gut dysbiosis will improve the outcome of these patients.
Keywords: pulmonary hypertension; microbiota; vitamin C; vitamin D; iron; diet pulmonary hypertension; microbiota; vitamin C; vitamin D; iron; diet
MDPI and ACS Style

Callejo, M.; Barberá, J.A.; Duarte, J.; Perez-Vizcaino, F. Impact of Nutrition on Pulmonary Arterial Hypertension. Nutrients 2020, 12, 169.

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