Face-to-Face and Digital Multidomain Lifestyle Interventions to Enhance Cognitive Reserve and Reduce Risk of Alzheimer’s Disease and Related Dementias: A Review of Completed and Prospective Studies
Abstract
:1. Introduction
From Single-Domain to Multi-Domain Interventions
2. Methods
3. Results
3.1. Completed Face-to-Face (FTF) Multidomain Interventions
3.1.1. Prevention of Dementia by Intensive Vascular Care (preDIVA)
3.1.2. The Multidomain Alzheimer’s Prevention Trial (MAPT)
3.1.3. The Finish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER)
3.1.4. The Systolic Blood Pressure Intervention Trial (SPRINT; SPRINT-MIND)
3.2. On-Going and Prospective Face-to-Face (FTF) Multidomain Interventions
3.2.1. Age Well.de
3.2.2. Systematic Multi-Domain Alzheimer’s Risk Reduction Trial (SMARRT)
3.2.3. The Multimodal Preventive Trial for Alzheimer′s Disease (MIND-ADmini)
3.2.4. The Multiple Nonpharmacological Interventions Study (EmuNI)
3.2.5. Taiwan Multidomain Intervention Efficacy Study—National Taiwan University Hospital
3.2.6. The Body, Brain, Life—General Practice Lifestyle Modification Program Study (BBL-GPLMP)
3.3. On-Going and Prospective World Wide Fingers Studies
3.4. On-Going and Prospective Multidomain Interventions
3.4.1. The Maintain Your Brain Study (MYB)
3.4.2. The Digital Cognitive Multidomain Alzheimer’s Risk Velocity Study (DC-MARVEL)
3.4.3. The Body, Brain, Life for Cognitive Decline Study (BBL-CD)
3.4.4. Healthy Ageing Through Internet Counselling in the Elderly (HATICE)
4. Conclusions
Author Contributions
Funding
Conflicts of Interest
References
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Study Title | Study Sample | Intervention Components | Study Length & Intervention Frequency | Primary Outcomes | Other Outcomes | Adherence/Attrition | Limitations |
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FINGER |
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MAPT |
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preDIVA |
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SPRINT-MIND |
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Study Title | Sample/Sampling Method | Interventions | Study Length & Intervention Frequency | Main Outcomes | Issues Addressed |
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Age well.de |
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SMARRT |
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EMuNI |
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MIND-ADmini |
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Taiwan Multidomain Intervention Efficacy Study |
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Brain, Body, Life: General Practice, Lifestyle Modification Program (BBL-GPLMP) |
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Authors/Date | Sample/Sampling Method | Interventions | Study Length & Intervention Frequency | Main Outcomes | Differentiating Factors from FINGER |
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POINTER |
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SINGER |
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MIND-CHINA |
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Title | Sample/Sampling Method | Interventions | Availability | Study Length | Primary Outcomes | Issues Addressed |
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MYB |
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DC-MARVEL |
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BBL-CD |
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HATICE |
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© 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
Share and Cite
Bott, N.T.; Hall, A.; Madero, E.N.; Glenn, J.M.; Fuseya, N.; Gills, J.L.; Gray, M. Face-to-Face and Digital Multidomain Lifestyle Interventions to Enhance Cognitive Reserve and Reduce Risk of Alzheimer’s Disease and Related Dementias: A Review of Completed and Prospective Studies. Nutrients 2019, 11, 2258. https://doi.org/10.3390/nu11092258
Bott NT, Hall A, Madero EN, Glenn JM, Fuseya N, Gills JL, Gray M. Face-to-Face and Digital Multidomain Lifestyle Interventions to Enhance Cognitive Reserve and Reduce Risk of Alzheimer’s Disease and Related Dementias: A Review of Completed and Prospective Studies. Nutrients. 2019; 11(9):2258. https://doi.org/10.3390/nu11092258
Chicago/Turabian StyleBott, Nicholas T., Aidan Hall, Erica N. Madero, Jordan M. Glenn, Nami Fuseya, Joshua L. Gills, and Michelle Gray. 2019. "Face-to-Face and Digital Multidomain Lifestyle Interventions to Enhance Cognitive Reserve and Reduce Risk of Alzheimer’s Disease and Related Dementias: A Review of Completed and Prospective Studies" Nutrients 11, no. 9: 2258. https://doi.org/10.3390/nu11092258