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Health Benefits of β-Hydroxy-β-Methylbutyrate (HMB) Supplementation in Addition to Physical Exercise in Older Adults: A Systematic Review with Meta-Analysis

1
Human Performance and Sports Science Laboratory, Faculty of Sport Sciences, University of Murcia, 30100 Murcia, Spain
2
Faculty of Physical Education and Sport, Charles University, 16252 Prague, Czech Republic
*
Author to whom correspondence should be addressed.
Nutrients 2019, 11(9), 2082; https://doi.org/10.3390/nu11092082
Received: 13 August 2019 / Revised: 27 August 2019 / Accepted: 29 August 2019 / Published: 3 September 2019
Both regular exercise training and beta-hydroxy-beta-methylbutyrate (HMB) supplementation are shown as effective treatments to delay or reverse frailty and reduce cognitive impairment in older people. However, there is very little evidence on the true benefits of combining both strategies. The aim of this meta-analysis was to quantify the effects of exercise in addition to HMB supplementation, on physical and cognitive health in older adults. Data from 10 randomized controlled trials (RCTs) investigating the effect of HMB supplementation and physical function in adults aged 50 years or older were analyzed, involving 384 participants. Results showed that HMB supplementation in addition to physical exercise has no or fairly low impact in improving body composition, muscle strength, or physical performance in adults aged 50 to 80 years, compared to exercise alone. There is a gap of knowledge on the beneficial effects of HMB combined with exercise to preserve cognitive functions in aging and age-related neurodegenerative diseases. Future RCTs are needed to refine treatment choices combining HMB and exercises for older people in particular populations, ages, and health status. Specifically, interventions in older adults aged 80 years or older, with cognitive impairment, frailty, or limited mobility are required. View Full-Text
Keywords: nutrition; resistance training; leucine; elderly; sarcopenia; neuromuscular function nutrition; resistance training; leucine; elderly; sarcopenia; neuromuscular function
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MDPI and ACS Style

Courel-Ibáñez, J.; Vetrovsky, T.; Dadova, K.; Pallarés, J.G.; Steffl, M. Health Benefits of β-Hydroxy-β-Methylbutyrate (HMB) Supplementation in Addition to Physical Exercise in Older Adults: A Systematic Review with Meta-Analysis. Nutrients 2019, 11, 2082. https://doi.org/10.3390/nu11092082

AMA Style

Courel-Ibáñez J, Vetrovsky T, Dadova K, Pallarés JG, Steffl M. Health Benefits of β-Hydroxy-β-Methylbutyrate (HMB) Supplementation in Addition to Physical Exercise in Older Adults: A Systematic Review with Meta-Analysis. Nutrients. 2019; 11(9):2082. https://doi.org/10.3390/nu11092082

Chicago/Turabian Style

Courel-Ibáñez, Javier; Vetrovsky, Tomas; Dadova, Klara; Pallarés, Jesús G.; Steffl, Michal. 2019. "Health Benefits of β-Hydroxy-β-Methylbutyrate (HMB) Supplementation in Addition to Physical Exercise in Older Adults: A Systematic Review with Meta-Analysis" Nutrients 11, no. 9: 2082. https://doi.org/10.3390/nu11092082

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