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Red Wine Grape Pomace Attenuates Atherosclerosis and Myocardial Damage and Increases Survival in Association with Improved Plasma Antioxidant Activity in a Murine Model of Lethal Ischemic Heart Disease

1
Department of Nutrition, Diabetes, and Metabolism, School of Medicine, Pontificia Universidad Católica, Santiago 8330033, Chile
2
Center of Molecular Nutrition and Chronic Diseases, School of Medicine, Pontificia Universidad Católica, Santiago 8330033, Chile
3
Biomedical Imaging Center, Department of Electrical Engineering, School of Engineering, Pontificia Universidad Católica, Santiago 7820436, Chile
4
Millennium Nucleus for Cardiovascular Magnetic Resonance, Santiago 7820436, Chile
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Department of Radiology, School of Medicine, Pontificia Universidad Católica, Santiago 8330033, Chile
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Department of Electrical Engineering, School of Engineering, Pontificia Universidad Católica, Santiago 7820436, Chile
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Division of Cardiovascular Diseases, School of Medicine, Pontificia Universidad Católica, Santiago 8330033, Chile
*
Author to whom correspondence should be addressed.
Equal contribution.
Nutrients 2019, 11(9), 2135; https://doi.org/10.3390/nu11092135
Received: 31 July 2019 / Revised: 29 August 2019 / Accepted: 2 September 2019 / Published: 6 September 2019
A healthy dietary pattern and high quality nutrient intake reduce atherosclerotic cardiovascular disease risk. Red wine grape pomace (RWGP)—a rich natural source of dietary fiber and antioxidants—appears to be a potential functional food ingredient. The impact of a dietary supplementation with RWGP flour was evaluated in atherogenic diet-fed SR-B1 KO/ApoER61h/h mice, a model of lethal ischemic heart disease. SR-B1 KO/ApoER61h/h mice were fed with atherogenic (high fat, cholesterol, and cholic acid, HFC) diet supplemented with: (a) 20% chow (HFC-Control), (b) 20% RWGP flour (HFC-RWGP), or (c) 10% chow/10% oat fiber (HFC-Fiber); and survival time was evaluated. In addition, SR-B1 KO/ApoER61h/h mice were fed for 7 or 14 days with HFC-Control or HFC-RWGP diets and plasma lipid levels, inflammation, oxidative damage, and antioxidant activity were measured. Atherosclerosis and myocardial damage were assessed by histology and magnetic resonance imaging, respectively. Supplementation with RWGP reduced premature death, changed TNF-α and IL-10 levels, and increased plasma antioxidant activity. Moreover, decreased atheromatous aortic and brachiocephalic plaque sizes and attenuated myocardial infarction and dysfunction were also observed. These results suggest that RWGP flour intake may be used as a non-pharmacological therapeutic approach, contributing to decreased progression of atherosclerosis, reduced coronary heart disease, and improved cardiovascular outcomes. View Full-Text
Keywords: atherosclerosis; oxidative stress; magnetic resonance imaging; fiber and antioxidants; grape pomace atherosclerosis; oxidative stress; magnetic resonance imaging; fiber and antioxidants; grape pomace
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MDPI and ACS Style

Rivera, K.; Salas-Pérez, F.; Echeverría, G.; Urquiaga, I.; Dicenta, S.; Pérez, D.; de la Cerda, P.; González, L.; Andia, M.E.; Uribe, S.; Tejos, C.; Martínez, G.; Busso, D.; Irarrázaval, P.; Rigotti, A. Red Wine Grape Pomace Attenuates Atherosclerosis and Myocardial Damage and Increases Survival in Association with Improved Plasma Antioxidant Activity in a Murine Model of Lethal Ischemic Heart Disease. Nutrients 2019, 11, 2135. https://doi.org/10.3390/nu11092135

AMA Style

Rivera K, Salas-Pérez F, Echeverría G, Urquiaga I, Dicenta S, Pérez D, de la Cerda P, González L, Andia ME, Uribe S, Tejos C, Martínez G, Busso D, Irarrázaval P, Rigotti A. Red Wine Grape Pomace Attenuates Atherosclerosis and Myocardial Damage and Increases Survival in Association with Improved Plasma Antioxidant Activity in a Murine Model of Lethal Ischemic Heart Disease. Nutrients. 2019; 11(9):2135. https://doi.org/10.3390/nu11092135

Chicago/Turabian Style

Rivera, Katherine; Salas-Pérez, Francisca; Echeverría, Guadalupe; Urquiaga, Inés; Dicenta, Sara; Pérez, Druso; de la Cerda, Paula; González, Leticia; Andia, Marcelo E.; Uribe, Sergio; Tejos, Cristián; Martínez, Gonzalo; Busso, Dolores; Irarrázaval, Pablo; Rigotti, Attilio. 2019. "Red Wine Grape Pomace Attenuates Atherosclerosis and Myocardial Damage and Increases Survival in Association with Improved Plasma Antioxidant Activity in a Murine Model of Lethal Ischemic Heart Disease" Nutrients 11, no. 9: 2135. https://doi.org/10.3390/nu11092135

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