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Probiotics in Irritable Bowel Syndrome: An Up-to-Date Systematic Review

Centre for Nutrition, Department of Clinical Medicine, University of Bergen, 5009 Bergen, Norway
Division of Gastroenterology, Department of Medicine, Haukeland University Hospital, 5021 Bergen, Norway
National Centre of Functional Gastrointestinal Disorders, Haukeland University Hospital, 5021 Bergen, Norway
Department of Gastroenterology, Ankara University Faculty of Medicine, Mamak Ankara 06620, Turkey
Author to whom correspondence should be addressed.
Nutrients 2019, 11(9), 2048;
Received: 4 July 2019 / Revised: 15 August 2019 / Accepted: 27 August 2019 / Published: 2 September 2019
(This article belongs to the Special Issue Nutritional Management of Gastrointestinal Diseases and Disorders)
Irritable bowel syndrome (IBS) is a frequent functional gastrointestinal disorder, and alterations in the gut microbiota composition contributes to symptom generation. The exact mechanisms of probiotics in the human body are not fully understood, but probiotic supplements are thought to improve IBS symptoms through manipulation of the gut microbiota. The aim of this systematic review was to assess the latest randomized controlled trials (RCTs) evaluating the effect of probiotic supplementation on symptoms in IBS patients. A literature search was conducted in Medline (PubMed) until March 2019. RCTs published within the last five years evaluating effects of probiotic supplements on IBS symptoms were eligible. The search identified in total 35 studies, of which 11 met the inclusion criteria and were included in the systematic review. Seven studies (63.6%) reported that supplementation with probiotics in IBS patients significantly improved symptoms compared to placebo, whereas the remaining four studies (36.4%) did not report any significant improvement in symptoms after probiotic supplementation. Of note, three studies evaluated the effect of a mono-strain supplement, whereas the remaining eight trials used a multi-strain probiotic. Overall, the beneficial effects were more distinct in the trials using multi-strain supplements with an intervention of 8 weeks or more, suggesting that multi-strain probiotics supplemented over a period of time have the potential to improve IBS symptoms. View Full-Text
Keywords: irritable bowel syndrome; probiotics; gut microbiota irritable bowel syndrome; probiotics; gut microbiota
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MDPI and ACS Style

Dale, H.F.; Rasmussen, S.H.; Asiller, Ö.Ö.; Lied, G.A. Probiotics in Irritable Bowel Syndrome: An Up-to-Date Systematic Review. Nutrients 2019, 11, 2048.

AMA Style

Dale HF, Rasmussen SH, Asiller ÖÖ, Lied GA. Probiotics in Irritable Bowel Syndrome: An Up-to-Date Systematic Review. Nutrients. 2019; 11(9):2048.

Chicago/Turabian Style

Dale, Hanna F., Stella H. Rasmussen, Özgün Ö. Asiller, and Gülen A. Lied. 2019. "Probiotics in Irritable Bowel Syndrome: An Up-to-Date Systematic Review" Nutrients 11, no. 9: 2048.

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