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Open AccessArticle

Melon GliSODin® Prevents Diet-Induced NASH Onset by Reducing Fat Synthesis and Improving Liver Function

1
Systems Biology Program, Graduate School of Media and Governance, Keio University, Kanagawa 252-0882, Japan
2
Health Science Laboratory, Keio Research Institute at SFC, Kanagawa 252-0882, Japan
3
Department of Ophthalmology, Keio University School of Medicine, Tokyo 160-8582, Japan
4
Department of Environment and Information Studies, Keio University, Kanagawa 252-0882, Japan
*
Authors to whom correspondence should be addressed.
Nutrients 2019, 11(8), 1779; https://doi.org/10.3390/nu11081779
Received: 9 July 2019 / Revised: 29 July 2019 / Accepted: 30 July 2019 / Published: 1 August 2019
A high-calorie diet causes fat accumulation and oxidative stress in the liver, leading to fatty liver and eventually non-alcoholic steatohepatitis (NASH). Melon GliSODin® is used as a nutritional supplement because of its antioxidant activity. This study aimed to assess the antioxidant activity of Melon GliSODin® and its effectiveness in preventing NASH, which primarily results from oxidative stress. Furthermore, we verified the protective effect of Melon GliSODin® by administering it to a mouse model of diet-induced NASH. Melon GliSODin® suppressed liver fibrosis and fat accumulation, which is characteristic of the NASH phenotype. Gene expression analysis confirmed the suppression of fat synthesis and activation of antioxidative mechanisms. These results show that Melon GliSODin® mitigates NASH onset at the molecular level, suggesting its potential application as a NASH preventive agent. View Full-Text
Keywords: non-alcoholic steatohepatitis; non-alcoholic fatty liver disease; oxidative stress; liver disease; natural products non-alcoholic steatohepatitis; non-alcoholic fatty liver disease; oxidative stress; liver disease; natural products
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MDPI and ACS Style

Nakamura, A.; Kitamura, N.; Yokoyama, Y.; Uchida, S.; Kumadaki, K.; Tsubota, K.; Watanabe, M. Melon GliSODin® Prevents Diet-Induced NASH Onset by Reducing Fat Synthesis and Improving Liver Function. Nutrients 2019, 11, 1779. https://doi.org/10.3390/nu11081779

AMA Style

Nakamura A, Kitamura N, Yokoyama Y, Uchida S, Kumadaki K, Tsubota K, Watanabe M. Melon GliSODin® Prevents Diet-Induced NASH Onset by Reducing Fat Synthesis and Improving Liver Function. Nutrients. 2019; 11(8):1779. https://doi.org/10.3390/nu11081779

Chicago/Turabian Style

Nakamura, Anna; Kitamura, Naho; Yokoyama, Yoko; Uchida, Sena; Kumadaki, Kayo; Tsubota, Kazuo; Watanabe, Mitsuhiro. 2019. "Melon GliSODin® Prevents Diet-Induced NASH Onset by Reducing Fat Synthesis and Improving Liver Function" Nutrients 11, no. 8: 1779. https://doi.org/10.3390/nu11081779

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