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Open AccessArticle

Phaseolus vulgaris L. Extract: Alpha-Amylase Inhibition against Metabolic Syndrome in Mice

1
Department of Neuroscience, Psychology, Drug Research and Child Health-Neurofarba-Pharmacology and Toxicology Section, University of Florence, 50139 Florence, Italy
2
Department of Pharmacy, University of Naples “Federico II” Naples, 80131 Naples, Italy
3
Department of Science of Health, School of Medicine and Surgery, University of Catanzaro, 88100 Catanzaro, Italy
4
Department of Experimental and Clinical Medicine, Anatomy and Histology Section, University of Florence, 50134 Florence, Italy
*
Author to whom correspondence should be addressed.
These authors contribute equally to this work.
Nutrients 2019, 11(8), 1778; https://doi.org/10.3390/nu11081778
Received: 21 June 2019 / Revised: 26 July 2019 / Accepted: 29 July 2019 / Published: 1 August 2019
(This article belongs to the Special Issue Diet and Metabolic Syndromes)
To examine the effects of the alpha-amylase inhibitor isoform 1 called phaseolamin, a standardized extract from white kidney beans (Phaseolus vulgaris L.) was tested against the hallmarks of metabolic syndrome. The efficacy of a per os repeated treatment with P. vulgaris extract (500 mg/kg) was compared with metformin (100 mg/kg) and atorvastatin (10 mg/kg) in a model of metabolic syndrome evoked by prolonged high fat diet (HFD; week 1 to week 19) in C57BL/6 mice. Bean extract and compounds administration started after metabolic syndrome establishment (week 11). P. vulgaris extract reduced the body weight overtime, as well as effectively lowered glycaemia, triglycerides, and cholesterol. On week 19, bean extract normalized the HFD-evoked tolerance to glucose and insulin. According to the phytochemical characterization, it inhibited the alpha-amylase activity. Animals treated with the extract were rescued from motor impairments and nociceptive threshold alterations induced by HFD. Specific organs analysis revealed that P. vulgaris extract decreased hepatic steatosis and lipid peroxidation in liver. It protected the heart from HFD oxidative alterations increasing the expression of the detoxifying enzymes catalase and glutathione reductase, and normalizing NADH dehydrogenase level. The histological analysis of aorta showed a protection about the development of fatty streaks in the muscular layers. In conclusion, a prolonged treatment with the standardized extract of P. vulgaris significantly reduced several pathological features related to a metabolic syndrome-like condition; a multifactorial approach that candidates this vegetal product as a possible therapeutic option against metabolic syndrome. View Full-Text
Keywords: P. vulgaris extract; metabolic syndrome; HFD, alpha-amylase inhibitor P. vulgaris extract; metabolic syndrome; HFD, alpha-amylase inhibitor
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MDPI and ACS Style

Micheli, L.; Lucarini, E.; Trallori, E.; Avagliano, C.; De Caro, C.; Russo, R.; Calignano, A.; Ghelardini, C.; Pacini, A.; Di Cesare Mannelli, L. Phaseolus vulgaris L. Extract: Alpha-Amylase Inhibition against Metabolic Syndrome in Mice. Nutrients 2019, 11, 1778. https://doi.org/10.3390/nu11081778

AMA Style

Micheli L, Lucarini E, Trallori E, Avagliano C, De Caro C, Russo R, Calignano A, Ghelardini C, Pacini A, Di Cesare Mannelli L. Phaseolus vulgaris L. Extract: Alpha-Amylase Inhibition against Metabolic Syndrome in Mice. Nutrients. 2019; 11(8):1778. https://doi.org/10.3390/nu11081778

Chicago/Turabian Style

Micheli, Laura; Lucarini, Elena; Trallori, Elena; Avagliano, Carmen; De Caro, Carmen; Russo, Roberto; Calignano, Antonio; Ghelardini, Carla; Pacini, Alessandra; Di Cesare Mannelli, Lorenzo. 2019. "Phaseolus vulgaris L. Extract: Alpha-Amylase Inhibition against Metabolic Syndrome in Mice" Nutrients 11, no. 8: 1778. https://doi.org/10.3390/nu11081778

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