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Open AccessArticle

Maternal Fiber Dietary Intakes during Pregnancy and Infant Allergic Disease

1
School of Medicine, University of Western Australia, 35 Stirling Highway, Crawley 6009, Western Australia, Australia
2
INRA Pays de la Loire, UR 1268 Biopolymers Interactions Assemblies, rue de la géraudière, BP 71627, Cedex 3, 44316 Nantes, France
3
Telethon Kids Institute, University of Western Australia, 15 Hospital Ave, Nedlands 6009, Western Australia, Australia
*
Author to whom correspondence should be addressed.
Nutrients 2019, 11(8), 1767; https://doi.org/10.3390/nu11081767
Received: 25 June 2019 / Revised: 26 July 2019 / Accepted: 29 July 2019 / Published: 1 August 2019
(This article belongs to the Special Issue Nutrition, Diet, and Allergic Diseases)
Maternal diet during pregnancy plays a likely role in infant immune development through both direct nutrient specific immunomodulatory effects and by modulating the composition and metabolic activity of the maternal gut microbiome. Dietary fibers, as major substrates for microbial fermentation, are of interest in this context. This is the first study to examine maternal intakes of different fiber sub-types and subsequent infant allergic disease. In an observational study of 639 mother–infant pairs (all infants had a family history of allergic disease) we examined maternal intakes of total fiber, soluble fiber, insoluble fiber, resistant starch, and prebiotic fiber, by a semi-quantitative food frequency questionnaire at 36–40 weeks’ gestation. Infants attended an allergy clinical assessment at 12 months of age, including skin prick testing to common allergens. Higher maternal dietary intakes of resistant starch were associated with reduced doctor diagnosed infant wheeze, adjusted odds ratio (aOR) 0.68 (95% CI 0.49, 0.95, p = 0.02). However, in contrast, higher maternal intakes of resistant starch were associated with higher risk of parent reported eczema aOR 1.27 (95% CI 1.09, 1.49, p < 0.01) and doctor diagnosed eczema aOR 1.19 (95% CI 1.01, 1.41, p = 0.04). In conclusion, maternal resistant starch consumption was differentially associated with infant phenotypes, with reduced risk of infant wheeze, but increased risk of eczema. View Full-Text
Keywords: dietary fiber; allergic disease; pregnancy; infant; resistant starch dietary fiber; allergic disease; pregnancy; infant; resistant starch
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MDPI and ACS Style

Pretorius, R.A.; Bodinier, M.; Prescott, S.L.; Palmer, D.J. Maternal Fiber Dietary Intakes during Pregnancy and Infant Allergic Disease. Nutrients 2019, 11, 1767.

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