Next Article in Journal
A Traditional Mediterranean Diet Effectively Reduces Inflammation and Improves Cardiovascular Health
Next Article in Special Issue
Pre-Conception Maternal Food Intake and the Association with Childhood Allergies
Previous Article in Journal
Sugar-Sweetened Beverages and Cardiometabolic Health: An Update of the Evidence
Previous Article in Special Issue
Maternal Fiber Dietary Intakes during Pregnancy and Infant Allergic Disease
Open AccessReview

Prebiotics: Mechanisms and Preventive Effects in Allergy

1
INRA Pays de la Loire, UR1268 Biopolymers Interactions Assemblies (BIA), rue de la géraudière, BP 71627, 44316 Nantes Cedex 01, France
2
Telethon Kids Institute, University of Western Australia, 15 Hospital Ave, Nedlands, Western Australia 6009, Australia
3
School of Medicine, University of Western Australia, 35 Stirling Highway, Crawley, Western Australia 6009, Australia
4
Department of Dermatology, Nantes University Hospital, 44035 Nantes, France
5
UMR1280 Physiopathology of Nutritional Adaptations (PhAN), INRA, 44035 Nantes, France
*
Author to whom correspondence should be addressed.
Nutrients 2019, 11(8), 1841; https://doi.org/10.3390/nu11081841
Received: 11 July 2019 / Revised: 31 July 2019 / Accepted: 1 August 2019 / Published: 8 August 2019
(This article belongs to the Special Issue Nutrition, Diet, and Allergic Diseases)
Allergic diseases now affect over 30% of individuals in many communities, particularly young children, underscoring the need for effective prevention strategies in early life. These allergic conditions have been linked to environmental and lifestyle changes driving the dysfunction of three interdependent biological systems: microbiota, epithelial barrier and immune system. While this is multifactorial, dietary changes are of particular interest in the altered establishment and maturation of the microbiome, including the associated profile of metabolites that modulate immune development and barrier function. Prebiotics are non-digestible food ingredients that beneficially influence the health of the host by 1) acting as a fermentable substrate for some specific commensal host bacteria leading to the release of short-chain fatty acids in the gut intestinal tract influencing many molecular and cellular processes; 2) acting directly on several compartments and specifically on different patterns of cells (epithelial and immune cells). Nutrients with prebiotic properties are therefore of central interest in allergy prevention for their potential to promote a more tolerogenic environment through these multiple pathways. Both observational studies and experimental models lend further credence to this hypothesis. In this review, we describe both the mechanisms and the therapeutic evidence from preclinical and clinical studies exploring the role of prebiotics in allergy prevention. View Full-Text
Keywords: prebiotics; mechanisms; allergy; microbiota; immune system; epithelial barrier; clinical studies; preclinical studies prebiotics; mechanisms; allergy; microbiota; immune system; epithelial barrier; clinical studies; preclinical studies
Show Figures

Figure 1

MDPI and ACS Style

Brosseau, C.; Selle, A.; Palmer, D.J.; Prescott, S.L.; Barbarot, S.; Bodinier, M. Prebiotics: Mechanisms and Preventive Effects in Allergy. Nutrients 2019, 11, 1841.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop