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Sesame Lignans Suppress Age-Related Cognitive Decline in Senescence-Accelerated Mice

1
Institute for Health Care Science, Suntory Wellness Limited, Kyoto 619-0284, Japan
2
Graduate Division of Nutritional and Environmental Sciences, University of Shizuoka, Shizuoka 422-8526, Japan
3
Department of Microbiology and Immunology, Aichi Medical University, Aichi 480-1195, Japan
4
School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka 422-8526, Japan
*
Author to whom correspondence should be addressed.
Nutrients 2019, 11(7), 1582; https://doi.org/10.3390/nu11071582
Received: 31 May 2019 / Revised: 29 June 2019 / Accepted: 9 July 2019 / Published: 12 July 2019
(This article belongs to the Special Issue Benefits of Dietary Phytochemicals)
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Abstract

Sesame lignans, which are biologically active compounds present in sesame seeds and oil, are known to have neuroprotective effects in several models of brain dysfunction. However, the effects of sesame lignans on age-related brain dysfunction are not clear and were thus investigated in the present study using a senescence-accelerated mouse (SAMP10). Two-month-old male SAMP10 mice were administrated a basal diet with 0% or 0.05% sesame lignans for two months, or with 0%, 0.02%, or 0.05% sesame lignans for 10 months and subjected to step-through passive avoidance tasks and forced swim tests. Reactive carbonyl species (RCs) were evaluated as markers of oxidative stress using a recently developed comprehensive analytical method. Both learning time in passive avoidance tasks and immobile time in forced swim tests became longer with aging (p < 0.05). However, the administration of sesame lignans significantly ameliorated age-related effects in both tests (p < 0.05). Age-related increases in RCs such as 4-hydroxy-2-nonenal in the cerebral cortex and liver were reduced in mice fed sesame lignans. These results suggest that sesame lignans can prevent age-related brain dysfunction via anti-oxidative activity. View Full-Text
Keywords: sesame lignans; sesamin; episesamin; cognitive decline; depression; SAMP10; senescence-accelerated mouse; reactive carbonyl sesame lignans; sesamin; episesamin; cognitive decline; depression; SAMP10; senescence-accelerated mouse; reactive carbonyl
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Shimoyoshi, S.; Takemoto, D.; Ono, Y.; Kitagawa, Y.; Shibata, H.; Tomono, S.; Unno, K.; Wakabayashi, K. Sesame Lignans Suppress Age-Related Cognitive Decline in Senescence-Accelerated Mice. Nutrients 2019, 11, 1582.

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