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Phytochemicals in Prostate Cancer: From Bioactive Molecules to Upcoming Therapeutic Agents

Student Research Committee, School of Medicine, Bam University of Medical Sciences, Bam 44340847, Iran
Antimicrobial and Biocontrol Agents Unit, Department of Biochemistry, Faculty of Science, University of Yaounde I, Ngoa Ekelle, Annex Fac. Sci, Yaounde 812, Cameroon
Institute for Medical Research and Medicinal Plants Studies, Yaoundé 13033, Cameroon
Antimicrobial Agents Unit, Laboratory for Phytobiochemistry and Medicinal Plants Studies, Department of Biochemistry, Faculty of Science, University of Yaoundé I, Messa-Yaoundé 812, Cameroon
Applied Microbiology, Biotechnology and Nanotechnology Laboratory, Department of Microbiology, Edo University, Iyamho, Edo State 300271, Nigeria
Department of Urology, Shohada-e-Tajrish Hospital, Shahid Beheshti University of Medical Sciences, Tehran 1989934148, Iran
Department of Agriculture and Animal Health, University of South Africa, Private Bag X6, Florida 1710, South Africa
Department of Nutrition and Dietetics, Faculty of Pharmacy, University of Concepcion, Concepcion 4070386, Chile
Department of Chemistry, University of Alabama in Huntsville, Huntsville, AL 35899, USA
LEPABE–Department of Chemical Engineering, Faculty of Engineering, University of Porto, Rua Dr. Roberto Frias, s/n, 4200-465 Porto, Portugal
Faculty of Medicine, University of Porto, Alameda Prof. Hernâni Monteiro, 4200-319 Porto, Portugal
Institute for Research and Innovation in Health (i3S), University of Porto, 4200-135 Porto, Portugal
Department of Clinical Oncology, Queen Elizabeth Hospital, Hong Kong, China
Zabol Medicinal Plants Research Center, Zabol University of Medical Sciences, Zabol 61615-585, Iran
Authors to whom correspondence should be addressed.
Nutrients 2019, 11(7), 1483;
Received: 14 May 2019 / Revised: 22 June 2019 / Accepted: 27 June 2019 / Published: 29 June 2019
(This article belongs to the Special Issue Nutrition and Prostate Cancer)
PDF [962 KB, uploaded 7 July 2019]
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Prostate cancer is a heterogeneous disease, the second deadliest malignancy in men and the most commonly diagnosed cancer among men. Traditional plants have been applied to handle various diseases and to develop new drugs. Medicinal plants are potential sources of natural bioactive compounds that include alkaloids, phenolic compounds, terpenes, and steroids. Many of these naturally-occurring bioactive constituents possess promising chemopreventive properties. In this sense, the aim of the present review is to provide a detailed overview of the role of plant-derived phytochemicals in prostate cancers, including the contribution of plant extracts and its corresponding isolated compounds. View Full-Text
Keywords: prostate cancer; medicinal plants; phytotherapy; secondary metabolites; plant formulas prostate cancer; medicinal plants; phytotherapy; secondary metabolites; plant formulas

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Salehi, B.; Fokou, P.V.T.; Yamthe, L.R.T.; Tali, B.T.; Adetunji, C.O.; Rahavian, A.; Mudau, F.N.; Martorell, M.; Setzer, W.N.; Rodrigues, C.F.; Martins, N.; Cho, W.C.; Sharifi-Rad, J. Phytochemicals in Prostate Cancer: From Bioactive Molecules to Upcoming Therapeutic Agents. Nutrients 2019, 11, 1483.

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