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Open AccessArticle

Asymmetric and Symmetric Protein Arginine Dimethylation: Concept and Postprandial Effects of High-Fat Protein Meals in Healthy Overweight Men

1
Institute of Toxicology, Core Unit Proteomics, Hannover Medical School, 30623 Hannover, Germany
2
UMR PNCA, AgroParisTech, INRA, Université Paris-Saclay, 75005 Paris, France
*
Author to whom correspondence should be addressed.
The two authors contributed equally to the manuscript.
Nutrients 2019, 11(7), 1463; https://doi.org/10.3390/nu11071463
Received: 20 May 2019 / Revised: 17 June 2019 / Accepted: 24 June 2019 / Published: 27 June 2019
(This article belongs to the Special Issue The Effect of Diet and Nutrition on Postprandial Metabolism)
Asymmetric and symmetric dimethylarginine (ADMA and SDMA, respectively) are risk factors for the cardiovascular and renal systems. There is a paucity of data in humans regarding variations of protein L-arginine (Arg) methylation leading to ADMA and SDMA. In this study, we introduced and used Arg dimethylation indices based on the creatinine-corrected urinary excretion of SDMA and ADMA, and its major metabolite dimethylamine (DMA). The main objective of the present study was to assess whether, and to which extent, a high-fat protein meal (HFM), a classical allostatic load eliciting various adverse effects, may contribute to Arg dimethylation in proteins in humans. Reliable gas chromatography–mass spectrometry methods were used to measure the concentration of ADMA, DMA, SDMA, and creatinine in spot urine samples collected before (0 h), and after (2, 4, 6 h) three HFM sessions in 10 healthy overweight individuals. At baseline, urinary ADMA, DMA, and SDMA excretion correlated positively with circulating TNF-α and IL-6. Arg dimethylation indices did not change postprandially. Our study shows that three HFMs do not contribute to Arg dimethylation in proteins. The proposed indices should be useful to determine extent and status of the whole-body Arg dimethylation in proteins in humans under various conditions. View Full-Text
Keywords: ADMA; arginine; SDMA; DMA; PRMT ADMA; arginine; SDMA; DMA; PRMT
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MDPI and ACS Style

Bollenbach, A.; Huneau, J.-F.; Mariotti, F.; Tsikas, D. Asymmetric and Symmetric Protein Arginine Dimethylation: Concept and Postprandial Effects of High-Fat Protein Meals in Healthy Overweight Men. Nutrients 2019, 11, 1463. https://doi.org/10.3390/nu11071463

AMA Style

Bollenbach A, Huneau J-F, Mariotti F, Tsikas D. Asymmetric and Symmetric Protein Arginine Dimethylation: Concept and Postprandial Effects of High-Fat Protein Meals in Healthy Overweight Men. Nutrients. 2019; 11(7):1463. https://doi.org/10.3390/nu11071463

Chicago/Turabian Style

Bollenbach, Alexander; Huneau, Jean-François; Mariotti, François; Tsikas, Dimitrios. 2019. "Asymmetric and Symmetric Protein Arginine Dimethylation: Concept and Postprandial Effects of High-Fat Protein Meals in Healthy Overweight Men" Nutrients 11, no. 7: 1463. https://doi.org/10.3390/nu11071463

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