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Amino Acids and Hypertension in Adults

1
Department of Experimental Medicine-Medical Pathophysiology, Food Science and Endocrinology Section; Sapienza University of Rome, 00185 Rome, Italy
2
Department of Biochemical Sciences “A. Rossi-Fanelli”; Sapienza University of Rome, Piazzale Aldo Moro 5, 00185 Rome, Italy
3
Department of Internal Medicine and Medical Specialties, Sapienza University of Rome, Viale del Policlinico 155, 00165 Rome, Italy
*
Author to whom correspondence should be addressed.
Nutrients 2019, 11(7), 1459; https://doi.org/10.3390/nu11071459
Received: 23 May 2019 / Revised: 12 June 2019 / Accepted: 19 June 2019 / Published: 27 June 2019
(This article belongs to the Special Issue Nutrients Intake and Hypertension)
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PDF [242 KB, uploaded 27 June 2019]

Abstract

Accumulating evidence suggests a potential role of dietary protein among nutritional factors interfering with the regulation of blood pressure. Dietary protein source (plant versus animal protein), and especially, protein composition in terms of amino acids has been postulated to interfere with mechanisms underlying the development of hypertension. Recently, mounting interest has been directed at amino acids in hypertension focusing on habitual dietary intake and their circulating levels regardless of single amino acid dietary supplementation. The aim of the present review was to summarize epidemiological evidence concerning the connection between amino acids and hypertension. Due to the large variability in methodologies used for assessing amino acid levels and heterogeneity in the results obtained, it was not possible to draw robust conclusions. Indeed, some classes of amino acids or individual amino acids showed non-causative association with blood pressure as well as the incidence of hypertension, but the evidence was far from being conclusive. Further research should be prompted for a thorough understanding of amino acid effects and synergistic actions of different amino acid classes on blood pressure regulation. View Full-Text
Keywords: amino acids; blood pressure; humans amino acids; blood pressure; humans
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Poggiogalle, E.; Fontana, M.; Giusti, A.M.; Pinto, A.; Iannucci, G.; Lenzi, A.; Donini, L.M. Amino Acids and Hypertension in Adults. Nutrients 2019, 11, 1459.

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