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Weight Loss and Hypertension in Obese Subjects

Department of Medicine, Section of Geriatrics, University of Verona Healthy Aging Center, Verona, Piazzale Stefani 1, 37126 Verona, Italy
Author to whom correspondence should be addressed.
Nutrients 2019, 11(7), 1667;
Received: 20 May 2019 / Revised: 15 July 2019 / Accepted: 16 July 2019 / Published: 21 July 2019
(This article belongs to the Special Issue Nutrients Intake and Hypertension)
Arterial hypertension is strongly related to overweight and obesity. In obese subjects, several mechanisms may lead to hypertension such as insulin and leptin resistance, perivascular adipose tissue dysfunction, renal impairment, renin-angiotensin-aldosterone-system activation and sympathetic nervous system activity. Weight loss (WL) seems to have positive effects on blood pressure (BP). The aim of this review was to explain the mechanisms linking obesity and hypertension and to evaluate the main studies assessing the effect of WL on BP. We analysed studies published in the last 10 years (13 studies either interventional or observational) showing the effect of WL on BP. Different WL strategies were taken into account—diet and lifestyle modification, pharmacological intervention and bariatric surgery. Although a positive effect of WL could be identified in each study, the main difference seems to be the magnitude and the durability of BP reduction over time. Nevertheless, further follow-up data are needed: there is still a lack of evidence about long term effects of WL on hypertension. Hence, given the significant results obtained in several recent studies, weight management should always be pursued in obese patients with hypertension. View Full-Text
Keywords: hypertension; weight loss; obesity hypertension; weight loss; obesity
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MDPI and ACS Style

Fantin, F.; Giani, A.; Zoico, E.; Rossi, A.P.; Mazzali, G.; Zamboni, M. Weight Loss and Hypertension in Obese Subjects. Nutrients 2019, 11, 1667.

AMA Style

Fantin F, Giani A, Zoico E, Rossi AP, Mazzali G, Zamboni M. Weight Loss and Hypertension in Obese Subjects. Nutrients. 2019; 11(7):1667.

Chicago/Turabian Style

Fantin, Francesco, Anna Giani, Elena Zoico, Andrea P. Rossi, Gloria Mazzali, and Mauro Zamboni. 2019. "Weight Loss and Hypertension in Obese Subjects" Nutrients 11, no. 7: 1667.

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