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Open AccessReview

The Potential of Carnosine in Brain-Related Disorders: A Comprehensive Review of Current Evidence

1
Institute of Pathophysiology, Faculty of Medicine, Comenius University, 84215 Bratislava, Slovakia
2
Biomedical Research Center, Slovak Academy of Sciences, 81439 Bratislava, Slovakia
3
Monash Centre for Health Research and Implementation, School of Public Health and Preventive Medicine, Melbourne, VIC 3168, Australia
4
School of Medicine, IMPACT Strategic Research Centre, Barwon Health, Deakin University, Geelong, VIC 3220, Australia
5
Orygen, The Centre of Excellence in Youth Mental Health, the Department of Psychiatry and the Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Melbourne, VIC 3052, Australia
6
Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield S10 2HQ, UK
7
Faculty of Physical Education and Sports, Comenius University, 81469 Bratislava, Slovakia
*
Authors to whom correspondence should be addressed.
Nutrients 2019, 11(6), 1196; https://doi.org/10.3390/nu11061196
Received: 30 April 2019 / Revised: 17 May 2019 / Accepted: 23 May 2019 / Published: 28 May 2019
(This article belongs to the Special Issue Diet and Mental Health)
Neurological, neurodegenerative, and psychiatric disorders represent a serious burden because of their increasing prevalence, risk of disability, and the lack of effective causal/disease-modifying treatments. There is a growing body of evidence indicating potentially favourable effects of carnosine, which is an over-the-counter food supplement, in peripheral tissues. Although most studies to date have focused on the role of carnosine in metabolic and cardiovascular disorders, the physiological presence of this di-peptide and its analogues in the brain together with their ability to cross the blood-brain barrier as well as evidence from in vitro, animal, and human studies suggest carnosine as a promising therapeutic target in brain disorders. In this review, we aim to provide a comprehensive overview of the role of carnosine in neurological, neurodevelopmental, neurodegenerative, and psychiatric disorders, summarizing current evidence from cell, animal, and human cross-sectional, longitudinal studies, and randomized controlled trials. View Full-Text
Keywords: carnosine; L-histidine; β-alanine; brain; cognition; treatment; psychiatry; neurology; nervous system carnosine; L-histidine; β-alanine; brain; cognition; treatment; psychiatry; neurology; nervous system
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MDPI and ACS Style

Schön, M.; Mousa, A.; Berk, M.; Chia, W.L.; Ukropec, J.; Majid, A.; Ukropcová, B.; de Courten, B. The Potential of Carnosine in Brain-Related Disorders: A Comprehensive Review of Current Evidence. Nutrients 2019, 11, 1196.

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