Next Article in Journal
Flavonoids and the Risk of Gastric Cancer: An Exploratory Case-Control Study in the MCC-Spain Study
Previous Article in Journal
Children’s Dietary Quality and Micronutrient Adequacy by Food Security in the Household and among Household Children
Previous Article in Special Issue
Protective Effects of Omega-3 Fatty Acids in Cancer-Related Complications
Article Menu
Issue 5 (May) cover image

Export Article

Open AccessArticle

The Effect of Omega-3 and Omega-6 Polyunsaturated Fatty Acids on the Production of Cyclooxygenase and Lipoxygenase Metabolites by Human Umbilical Vein Endothelial Cells

1
Institute of Marine Research, PO Box 1870 Nordnes, N-5817 Bergen, Norway
2
Department of Biomedicine, University of Bergen, Jonas Lies vei 91, N-5009 Bergen, Norway
3
Department of Chemistry, Organic Analysis and Catalysis Laboratory, Simon Bolivar University, Caracas 1080A, Venezuela
*
Author to whom correspondence should be addressed.
Nutrients 2019, 11(5), 966; https://doi.org/10.3390/nu11050966
Received: 8 March 2019 / Revised: 23 April 2019 / Accepted: 24 April 2019 / Published: 27 April 2019
(This article belongs to the Special Issue Effects of Omega-3 Polyunsaturated Fatty Acids and Human Health)
  |  
PDF [1505 KB, uploaded 27 April 2019]
  |     |  

Abstract

Although the correlation between polyunsaturated fatty acids (PUFA) and the production of pro- and anti-inflammatory metabolites is well documented, little is known about the simultaneous effect of different PUFA on the production of cyclooxygenase and lipoxygenase metabolites. The present research examines the association between different omega-3 (ω-3) and omega-6 (ω-6) PUFA and the release of four cyclooxygenase and six lipoxygenase metabolites in cell medium by human umbilical vein endothelial cells (HUVEC). The different combinations of ω-3 and ω-6 PUFA were prepared according to a full 24 factorial design that enables studying not only the main effects but also the different interactions between fatty acids. In addition, interactions diagrams and principal component analysis were useful tools for interpreting higher order interactions. To the best of our knowledge, this is the first report addressing the combined effect of ω-3 and ω-6 PUFA on the signaling of prostaglandins, prostacyclins, leukotrienes and resolvins by HUVEC. View Full-Text
Keywords: polyunsaturated fatty acids; docosahexaenoic acid; eicosapentaenoic acid; α-linolenic acid; arachidonic acid; human umbilical vein endothelial cells; eicosanoids; prostacyclins; leukotrienes; resolvins polyunsaturated fatty acids; docosahexaenoic acid; eicosapentaenoic acid; α-linolenic acid; arachidonic acid; human umbilical vein endothelial cells; eicosanoids; prostacyclins; leukotrienes; resolvins
Figures

Graphical abstract

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Supplementary material

SciFeed

Share & Cite This Article

MDPI and ACS Style

Araujo, P.; Belghit, I.; Aarsæther, N.; Espe, M.; Lucena, E.; Holen, E. The Effect of Omega-3 and Omega-6 Polyunsaturated Fatty Acids on the Production of Cyclooxygenase and Lipoxygenase Metabolites by Human Umbilical Vein Endothelial Cells. Nutrients 2019, 11, 966.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Nutrients EISSN 2072-6643 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top