Next Article in Journal
Protection of the Ovine Fetal Gut against Ureaplasma-Induced Chorioamnionitis: A Potential Role for Plant Sterols
Previous Article in Journal
The Effect of Omega-3 and Omega-6 Polyunsaturated Fatty Acids on the Production of Cyclooxygenase and Lipoxygenase Metabolites by Human Umbilical Vein Endothelial Cells
Article Menu
Issue 5 (May) cover image

Export Article

Open AccessArticle

Flavonoids and the Risk of Gastric Cancer: An Exploratory Case-Control Study in the MCC-Spain Study

1
Grupo de Investigación en Interacciones Gen-Ambiente y Salud (GIIGAS)/Instituto de Biomedicina (IBIOMED), Universidad de León, 24071 León, Spain
2
Unit of Nutrition and Cancer, Cancer Epidemiology Research Programme, Catalan Institute of Oncology (ICO), Bellvitge Biomedical Research Institute (IDIBELL), 08908 L’Hospitalet de Llobregat (Barcelona), Spain
3
Instituto de Investigación Sanitaria Illes Balears (IdISBa), Spain
4
Instituto de Salud Global de Barcelona (ISGlobal), 08003 Barcelona, Spain
5
CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), 28029 Madrid, Spain
6
Consortium for Biomedical Research in Epidemiology & Public Health (CIBER en Epidemiología y Salud Pública-CIBERESP), 28029 Madrid, Spain
7
Cancer Epidemiology Section, Public Health Division, Department of Health of Madrid, 28035 Madrid, Spain
8
Oncology Data Analytics Program (ODAP), Catalan Institute of Oncology (ICO), L’Hospitalet del Llobregat, 08003 Barcelona, Spain
9
ONCOBELL Program, Bellvitge Biomedical Research Institute (IDIBELL), L’Hospitalet de Llobregat, Spain
10
Public Health Institute of Navarra-IDISNA, 31003 Pamplona, Spain
11
University of Cantabria–IDIVAL, Santander, Spain
12
Cancer and Public Health Area, FISABIO-Public Health, 46020 Valencia, Spain
13
Department of Preventive Medicine and Public Health, University of Granada, 18071 Granada, Spain
14
Centro de Investigación en Recursos Naturales, Salud, y Medio Ambiente (RENSMA), Universidad de Huelva, 21071 Huelva, Spain
15
Department of Epidemiology, Regional Health Council, IMIB-Arrixaca, Murcia University, 30007 Murcia, Spain
16
Department of Epidemiology of Chronic Diseases, National Centre for Epidemiology, Carlos III Institute of Health, 28029 Madrid, Spain
17
Oncology Data Analytics Program (ODAP), Catalan Institute of Oncology (ICO), L’Hospitalet del Llobregat, 08908 Barcelona, Spain
18
ONCOBELL Program, Bellvitge Biomedical Research Institute (IDIBELL), L’Hospitalet de Llobregat, 08908 Barcelona, Spain
19
Department of Clinical Sciences, Faculty of Medicine, University of Barcelona, 08907 Barcelona, Spain
20
IMIM (Hospital del Mar Medical Research Institute), 08003 Barcelona, Spain
21
Universitat Pompeu Fabra (UPF), Departament de Ciències Experimentals i de la Salut, 08002 Barcelona, Spain
*
Author to whom correspondence should be addressed.
Nutrients 2019, 11(5), 967; https://doi.org/10.3390/nu11050967
Received: 16 March 2019 / Revised: 19 April 2019 / Accepted: 24 April 2019 / Published: 27 April 2019
  |  
PDF [993 KB, uploaded 9 May 2019]
  |     |  

Abstract

Several epidemiological studies have investigated the association between the dietary flavonoid intake and gastric cancer (GC) risk; however, the results remain inconclusive. Investigating the relationship between the different classes of flavonoids and the histological types and origin of GC can be of interest to the research community. We used data from a population-based multi-case control study (MCC-Spain) obtained from 12 different regions of Spain. 2700 controls and 329 GC cases were included in this study. Odds ratios (ORs) were calculated using the mixed effects logistic regression considering quartiles of flavonoid intakes and log2. Flavonoid intake was associated with a lower GC risk (ORlog2 = 0.76; 95% CI = 0.65–0.89; ORq4vsq1 = 0.60; 95%CI = 0.40–0.89; ptrend = 0.007). Inverse and statistically significant associations were observed with anthocyanidins, chalcones, dihydroflavonols and flavan-3-ols. The isoflavanoid intake was positively associated with higher cancer risk, but without reaching a statistical significance. In general, no differences were observed in the GC risk according to the location and histological type. The flavonoid intake seems to be a protective factor against GC within the MCC-study. This effect may vary depending on the flavonoid class but not by the histological type and location of the tumor. Broader studies with larger sample size and greater geographical variability are necessary. View Full-Text
Keywords: flavonoids; intake; gastric cancer; case-control study; MCC-Spain flavonoids; intake; gastric cancer; case-control study; MCC-Spain
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Supplementary material

SciFeed

Share & Cite This Article

MDPI and ACS Style

Vitelli Storelli, F.; Molina, A.J.; Zamora-Ros, R.; Fernández-Villa, T.; Roussou, V.; Romaguera, D.; Aragonés, N.; Obón-Santacana, M.; Guevara, M.; Gómez-Acebo, I.; Fernández-Tardón, G.; Molina-Barceló, A.; Olmedo-Requena, R.; Capelo, R.; Chirlaque, M.D.; Pérez-Gómez, B.; Moreno, V.; Castilla, J.; Rubín-García, M.; Pollán, M.; Kogevinas, M.; Lera, J.P.B.; Martín, V. Flavonoids and the Risk of Gastric Cancer: An Exploratory Case-Control Study in the MCC-Spain Study. Nutrients 2019, 11, 967.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Nutrients EISSN 2072-6643 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top