Next Article in Journal
Nutritional Outcome in Home Gastrostomy-Fed Children with Chronic Diseases
Next Article in Special Issue
Carbohydrate Availability and Physical Performance: Physiological Overview and Practical Recommendations
Previous Article in Journal
Acute Dietary Nitrate Supplementation Improves Flow Mediated Dilatation of the Superficial Femoral Artery in Healthy Older Males
Previous Article in Special Issue
Enhancement of Exercise Performance by 48 Hours, and 15-Day Supplementation with Mangiferin and Luteolin in Men
Open AccessArticle

The Association of Life’s Simple 7 with Aldosterone among African Americans in the Jackson Heart Study

1
Department of Medicine, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA
2
Department of Biomedical Informatics and Center for Biostatistics, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA
3
Division of Biostatistics, College of Public Health, The Ohio State University, Columbus, OH 43210, USA
4
Department of Medicine, Morehouse School of Medicine, Atlanta, GA 30310, USA
5
Division of Endocrinology, Diabetes, and Metabolism, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
6
Department of Medicine, University of Mississippi Medical Center, Jackson, MS 39216, USA
7
Department of Epidemiology & Prevention, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA
8
Division of Cardiovascular Diseases and Hypertension, Rutgers University Robert Wood Johnson Medical School, New Brunswick, NJ 08901, USA
*
Author to whom correspondence should be addressed.
Nutrients 2019, 11(5), 955; https://doi.org/10.3390/nu11050955
Received: 28 March 2019 / Revised: 19 April 2019 / Accepted: 22 April 2019 / Published: 26 April 2019
(This article belongs to the Special Issue Nutrition and Exercise Metabolism)
Background: Among African Americans (AAs), attaining higher levels of American Heart Association (AHA) ideal cardiovascular health (Life’s Simple 7 [LS7]) is associated with lower risk of diabetes and cardiovascular disease (CVD). We previously showed that aldosterone is associated with higher risk of diabetes and CVD in AAs. Thus, we investigated the association of LS7 metrics with aldosterone in the Jackson Heart Study (JHS). Methods: Ideal metrics were defined by AHA 2020 goals for health behaviors (smoking, dietary intake, physical activity, and body mass index) and health factors (total cholesterol, blood pressure, and fasting glucose). The number of ideal LS7 metrics attained at baseline were summed into a continuous score (0–7) and categorical groups (Poor: 0–1, Intermediate: 2–3, and Ideal: ≥4 ideal LS7 metrics). Multivariable linear regression was used. Results: Among 4,095 JHS participants (mean age 55 ± 13 years, 65% female), median serum aldosterone was 4.90, 4.30, and 3.70 ng/dL in the poor (n = 1132), intermediate (n = 2288) and ideal (n = 675) categories respectively. Aldosterone was 15% [0.85 (0.80, 0.90)] and 33% [0.67 (0.61, 0.75)] lower in the intermediate and ideal LS7 categories compared to the poor LS7 category. Each additional LS7 metric attained on continuous LS7 score (0–7) was associated with an 11% [0.89 (0.86, 0.91)] lower aldosterone level with variation by sex with women having a 15% lower aldosterone vs. 5% in men. Conclusions: Higher attainment of ideal LS7 metrics was associated with lower serum aldosterone among AAs with a greater magnitude of association among women compared to men. View Full-Text
Keywords: aldosterone; ideal cardiovascular health; Life’s Simple 7; African Americans; physical activity; body mass index; smoking; blood pressure; glucose; cholesterol. aldosterone; ideal cardiovascular health; Life’s Simple 7; African Americans; physical activity; body mass index; smoking; blood pressure; glucose; cholesterol.
MDPI and ACS Style

Kesireddy, V.; Tan, Y.; Kline, D.; Brock, G.; Odei, J.B.; Kluwe, B.; Effoe, V.S.; Echouffo Tcheugui, J.B.; Kalyani, R.R.; Sims, M.; Taylor, H.A.; Mongraw-Chaffin, M.; Akhabue, E.; Joseph, J.J. The Association of Life’s Simple 7 with Aldosterone among African Americans in the Jackson Heart Study. Nutrients 2019, 11, 955. https://doi.org/10.3390/nu11050955

AMA Style

Kesireddy V, Tan Y, Kline D, Brock G, Odei JB, Kluwe B, Effoe VS, Echouffo Tcheugui JB, Kalyani RR, Sims M, Taylor HA, Mongraw-Chaffin M, Akhabue E, Joseph JJ. The Association of Life’s Simple 7 with Aldosterone among African Americans in the Jackson Heart Study. Nutrients. 2019; 11(5):955. https://doi.org/10.3390/nu11050955

Chicago/Turabian Style

Kesireddy, Veena; Tan, Yubo; Kline, David; Brock, Guy; Odei, James B.; Kluwe, Bjorn; Effoe, Valery S.; Echouffo Tcheugui, Justin B.; Kalyani, Rita R.; Sims, Mario; Taylor, Herman A.; Mongraw-Chaffin, Morgana; Akhabue, Ehimare; Joseph, Joshua J. 2019. "The Association of Life’s Simple 7 with Aldosterone among African Americans in the Jackson Heart Study" Nutrients 11, no. 5: 955. https://doi.org/10.3390/nu11050955

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop